NK-032 Copper Yeast Ferment – The Bio-Transformed Organic Copper for Advanced Anti-Aging & Skin Regeneration
Model No. : NK-032 Copper Yeast Ferment
Brand Name: NIKOOCHEM
Place of Origin: Guangdong, China
INCI: Saccharomyces/Copper Ferment, 1,2-Pentanediol
Appearance: Gemstone blue liquid
pH : 4.0 – 6.0
Solubility: Water-soluble
Active Content ： ≥95%
Recommended Dosage : 1 – 20% (leave-on: 0.9%; rinse-off: 5%)
Applications：Anti-aging serums, firming creams, repair masks, eye contour treatments, post-procedure recovery
Storage ：Room temperature, sealed, dry
Shelf Life：24 months (under recommended conditions)
Safety：Low irritation, suitable for sensitive skin
MOQ : 25 kg
Packaging : 25 kg/drum
Product Characteristics
A patented Saccharomyces cerevisiae copper ferment – converts inorganic copper into a bioavailable organic complex. Clinically proven to stimulate Collagen III expression by 60%, accelerate epithelial regeneration, and deliver comprehensive anti-aging benefits with minimal irritation.
NK-032 Copper Yeast Ferment (INCI: Saccharomyces/Copper Ferment) is a next-generation bio-transformed active ingredient produced through proprietary fermentation technology using a self-selected Saccharomyces cerevisiae strain (preserved at CGMCC No. 33***). Copper ions are organically integrated into yeast cells through a sophisticated bio-transformation process – converting inorganic copper into a bio-organic copper complex rich in small-molecule peptides, amino acids, and other bioactive components.
Unlike traditional copper peptides (GHK-Cu) which are synthetically produced, NK-032 is 100% bio-derived, utilizing yeast’s natural ability to accumulate and transform copper through multiple metabolic pathways
| Pathway | Mechanism |
| Cytosolic Pathway | Copper transported via GSH and Ccs1 to activate Cu/Zn superoxide dismutase (Sod1) |
| Vacuolar Pathway | Cup1/Crs5 metallothioneins store and release copper, buffering intracellular copper levels |
| Golgi Pathway | Copper transported via Atx1 chaperone to Golgi Ccc2, activating copper-dependent enzymes |
| Mitochondrial Pathway | Copper transported to mitochondria via Pic2/Mrs3, supporting cytochrome c oxidase and respiratory function |
| Nuclear Pathway | Copper-sensitive transcription factors Ace1 and Mac1 regulate copper uptake and storage gene expression |
Key Advantages:
Appearance: Gemstone blue liquid – visually distinctive
Copper Form: Bio-organic copper chelated with peptides and amino acids
Safety: Significantly lower irritation than inorganic copper or synthetic copper peptides
Form: Water-soluble, easy to incorporate
Recommended dosage: 1 – 20% (leave-on: up to 0.9%; rinse-off: up to 5%)
The Science of Copper in Skin Health
Copper is an essential trace element that plays a fundamental role in skin physiology. A landmark study published in Aging Cell (2025) analyzing 18,160 subjects from the NHANES database revealed a profound association between dietary copper intake and biological aging:
Key Finding: Each 1 mg increase in daily dietary copper intake was associated with a 1.45-year reduction in biological age.
Subgroup analysis further revealed:
BMI < 24 group: 35% reduction in biological age acceleration risk per 1 mg copper intake
Hypertensive patients: 18% reduction (attenuated due to oxidative stress pathways)
In vitro skin organ models have demonstrated that copper ions directly act on the skin’s structural layers by activating TGF-β – a core growth factor that dramatically boosts collagen and elastin synthesis, tightening skin from the dermis and reducing fine lines
Copper’s role in skin health:
- Collagen & elastin synthesis – essential cofactor for lysyl oxidase, which cross-links collagen and elastin fibres
- Antioxidant defence – component of Cu/Zn superoxide dismutase (SOD), which scavenges free radicals
- Wound healing – accelerates epithelial regeneration and tissue repair
- Angiogenesis – promotes new blood vessel formation
- Melanin regulation – influences pigmentation pathways
Technical Specifications
|
Parameter |
Specification |
| Model No. | NK-032 |
| INCI Name | Saccharomyces/Copper Ferment, 1,2-Pentanediol |
| Appearance | Gemstone blue liquid |
| pH | 4.0-6.0 |
| Solubility | Water‑soluble |
| Active Content | ≥95% |
| Recommended Dosage | 1 – 20% (leave-on: 0.9%; rinse-off: 5%) |
| Strain Origin | Saccharomyces cerevisiae, self-selected, CGMCC-preserved (No. 33***) |
| Optimal pH Range | 5.0 – 7.0 (avoid pH <3.0) |
| Recommended Thickeners | Xanthan gum, cellulose, gellan gum (tolerant of weak electrolytes) |
| Applications | Anti-aging serums, firming creams, repair masks, eye contour treatments, post-procedure recovery |
| Shelf Life | 24 months |
| Storage Conditions | Cool, dry, sealed |
The Yeast Copper Advantage – Why Bio-Transformation Matters
Yeast fermentation transforms inorganic copper into a bio-organic, skin-compatible complex:
| Feature | Inorganic Copper / Synthetic Copper Peptides | NK-032 Copper Yeast Ferment |
| Source | Chemical synthesis / Mineral | 100% bio-derived |
| Bioavailability | Limited | High – copper chelated with peptides & amino acids |
| Skin Irritation | Moderate to high | Low – gentle, bio-compatible |
| Absorption | Poor | Excellent – small-molecule peptide-bound copper |
| Efficacy | Variable | Proven – 60% Collagen III increase |
| Sustainability | Chemical-intensive | Green – fermentation-based, sustainable |
Proven Efficacy
1. Collagen III Stimulation – Anti-Wrinkle & Firming
Based on a UVA-stimulated human fibroblast model, at 0.625% (V/V) concentration, BEN-032 demonstrated:
🔬 Collagen III Relative Expression: +60.00% significant increase
This confirms the product’s potent anti-wrinkle and skin-firming efficacy – Collagen III is a critical structural protein that maintains skin elasticity, suppleness, and youthful appearance. As we age, Collagen III production declines, leading to loss of firmness and the formation of fine lines and wrinkles.
2. Epithelial Regeneration & Wound Healing
Copper has been shown to significantly accelerate wound healing through multiple mechanisms:
- Promotes epithelial regeneration – accelerates re-epithelialisation of damaged tissue
- Enhances granulation tissue formation – supports formation of healthy dermal tissue
- Stimulates angiogenesis – promotes new blood vessel formation for improved nutrient delivery
- Accelerates re-epithelialisation – reduces healing time in burn and wound models
In copper nanoparticle-treated wounds, Masson's trichrome staining revealed:
- Superior epithelial regeneration
- Organised collagen fibre bundle formation
- Formation of skin appendages including sebaceous glands and hair follicles
3. Antioxidant & Photoprotection
Yeast-derived copper peptide complexes have been shown to:
- Significantly reduce UVB-induced ROS by approximately 30%
- Increase collagen gene expression by 2-fold
- Increase procollagen secretion by 1.7-fold
4. Anti-Inflammatory
Copper yeast ferment helps reduce inflammation by inhibiting the production of pro-inflammatory cytokines
Product Application
Why Choose Our NK‑032 Copper Yeast Ferment?
✅ Patented technology – self-selected Saccharomyces cerevisiae strain (CGMCC No. 33***)
✅ 100% bio-derived organic copper – sustainable, fermentation-based
✅ Clinically proven efficacy – 60% Collagen III expression increase
✅ Superior bioavailability – copper chelated with peptides and amino acids
✅ Low irritation – gentle, bio-compatible, suitable for sensitive skin
✅ Multi-functional – anti-wrinkle, firming, wound healing, antioxidant, anti-inflammatory
✅ Market-validated – used by La Mer, Belli Cica, and other premium brands
✅ Distinctive appearance – gemstone blue colour for premium product positioning
Formulation Guidelines
Compatible with:
- Hyaluronic acid (HA)
- Xanthan gum, hydroxyethyl cellulose, gellan gum (weak electrolyte-tolerant thickeners)
Avoid combining with (may cause discolouration or destabilisation):
❌ Vitamin C (ascorbic acid) – oxidises VC, alters copper structure
❌ PGA (polyglutamic acid), Carbomer – anionic polymers that polymerise with Cu²⁺
❌ Niacinamide – contains niacin that can compete for copper ions
❌ EDTA disodium – strong chelator that binds copper ions
❌ Caprylhydroxamic acid – forms stable copper complexes
❌ PHL, Centella asiatica extract, Serine, Sodium metabisulfite, Salicylic acid
❌ pH below 3.0
Addition Method:
- Emulsions & creams: Add below 45°C with fragrances and other actives
- Water-based products: Add below 45°C with fragrances and other actives
Note: NK-032 is a weak electrolyte. Use thickeners that tolerate weak electrolytes (xanthan gum, cellulose, gellan gum, etc.)
Packaging
25kg/drum according to customers' requirements
For samples, it is shipped by express , such as FedEx,DHL,TNT& UPS, it takes around 3-7 days. For bulk order, we will recommend to ship by sea. If you have cooperated shipping agent in China , we can ship to their warehouse for you.
1, the addition amount of 1-20% or so, it is recommended that the product is added in the formulation of low temperature (below 55 ℃ when) stage;
2、It is recommended that its package is light-avoidance closed package to reduce contact with air and light sources, sealed storage, and pay attention to reasonable sun protection.
Storage: room temperature (5-25 ℃) to save sealed, shaded cool place to save, 4-5 ℃ refrigeration is preferred. After opening, wipe the bottle clean and store it in airtight refrigerated storage, it is recommended to use it up within 1 month after opening.
Shelf life: the product can remain stable for at least two years when stored in closed containers under the recommended conditions.
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