Don't be a woman with spots—Excellent spot-removing and whitening ingredient-Nikoo™ SAP yeast peptide
Even in ordinary days, we should be beautiful and sparkling.
The beauty is endless and varied. Our colorful youth
should not have mottled faces.
Nikoo™ SAP yeast peptide is undoubtedly the most superior, most efficient and safest biological tyrosinase inhibitor to date. Its IC50 for B16V melanocytes is 10.9μM/ml, kojic acid is 400μM/ml, and arbutin is greater than 500μM/ml; its ability to inhibit tyrosinase activity is 50 times that of β-arbutin; its effect is 3 times stronger than hydroquinone, and its stability is good; it has zero cytotoxicity and no skin and mucous membrane irritation
Nikoo™ SAP yeast peptide has made a breakthrough in skin safety testing. The results of the cytotoxicity test showed that Nikoo™ SAP yeast peptide had no cytotoxicity, and the results of multiple skin irritation tests also showed no irritation. Under the same conditions, the percutaneous test of hydroquinone and resorcinol raw materials in rabbits showed that they had very obvious irritation and damage to the skin and mucous membranes.
Evaluation of the formation and whitening activity of melanin
The content and distribution of melanin in the skin play a decisive role in the color of human skin. Therefore, the research on the mechanism of melanin production has always been a hot topic. However, the formation of melanin is always related to tyrosinase from the beginning to the end. Studies have confirmed that this enzyme is the main rate-limiting enzyme in the formation of melanin, and its activity will directly affect the amount of melanin produced. This is also the reason why the whitening effect of skin whitening agents is often measured by testing the inhibitory ability of whitening agents during the development process.
The core active peptide of Nikoo™ SAP yeast polypeptide is a unique ingredient, in which 2-OH and 4-OH on the B ring are very close to the -OH structure on the aromatic ring of β-dopa and L-tyrosine, so it is easy to bind to the enzyme active center and produce a strong inhibition on the enzyme. The introduction of the C region peptide bond structure plays a good role in protecting and stabilizing the 2-OH and 4-OH structures, greatly enhancing their water solubility. At the same time, the C structure has a strong antioxidant ability.
Nikoo™ SAP yeast peptide has a strong inhibitory effect on tyrosinase activity. Further studies have shown that it can bind to the di-copper ion active center of tyrosinase and is a competitive inhibitor of tyrosinase. On the other hand, Nikoo™ SAP yeast peptide has good antioxidant properties, and the formation of melanin is preceded by two stages and an oxidation process.
In the mechanism of whitening and freckle removal, antioxidant and competitive inhibition are the two most common and important mechanisms of action, and Nikoo™ SAP yeast peptide has both of these effects.
The results of human experiments show that the L* value of the whitening cream with Nikoo™ SAP yeast peptide was significantly higher than that of the control group throughout the test period. The efficacy showed a significant change 14 days before the test. The whitening cream with 3.0% Nikoo™ SAP yeast peptide showed significantly higher whitening efficacy than the control group at 14, 28 and 42 days.
Notes
Please keep Nikoo™ SAP in the PH4.5-PH6.0 system. After adding and stabilizing, it can form a buffer system for skin health and whitening needs, and it is also conducive to the maximum stability of the activity of this raw material. It is recommended to add it below 50℃ to ensure that the activity of the raw material is not lost. If the raw material is left at room temperature for a long time, it may accelerate its oxidation and discoloration when exposed to air. Please place it with caution. It is necessary to consider adding a small amount of antioxidants in the formula system to extend and reach the shelf life of the product and maintain the maximum stability of the activity. We usually recommend adding 0.05%-0.2% sodium bisulfite. The reasonable usage amount needs to be determined according to the concentration of Nikoo™ SAP. After preparation, please strictly implement light-proof and airtight storage to facilitate the maximum stability of the product.
