NIKOO Chemical - Skincare Raw Material Supply and Custom Solution Specialist for 15 years.

Fuconin – Multi‑Target Soothing Complex for Sensitive, Reactive & Allergy‑Prone Skin

2026-05-20

A synergistic botanical blend of Centella asiatica, kava, skullcap, and a non‑steroidal anti‑inflammatory active – calms histamine‑induced itching, stabilises mast cells, and restores skin comfort.

Fuconin – Multi‑Target Soothing Complex for Sensitive, Reactive & Allergy‑Prone Skin 1

Product Overview:
Fuconin is a scientifically designed, water‑soluble liquid concentrate formulated to address the root causes of skin sensitivity, redness, itching, and inflammation. It combines four powerful actives:

Centella asiatica (Gotu Kola) root extract – rich in asiaticoside and madecassoside; stimulates type I & III collagen synthesis, soothes burning/stinging, strengthens the dermal matrix, and accelerates barrier repair.
Scutellaria baicalensis (Chinese skullcap) root extract – baicalin‑rich; inhibits elastase, scavenges free radicals, suppresses UV‑induced inflammation, and acts as a natural sebum regulator.
Piper methysticum (Kava) root extract – contains kavalactones; reduces neurogenic inflammation, blocks TRPV1 receptors, calms stinging and pain sensations, and provides fast relief from irritation.
Hydroxyphenyl propamidobenzoic acid – a potent non‑steroidal anti‑inflammatory and anti‑pruritic agent. At just 30 ppm, it significantly reduces histamine‑induced erythema, oedema, and scratching. It inhibits NF‑κB activation (prevents p65 phosphorylation) and reduces TNF‑α and IL‑8 release. Efficacy comparable to hydrocortisone but without steroid side effects.

**Key Benefits at a Glance:**
Benefit	Mechanism
🛡️ Calms itch & redness	Inhibits histamine release; reduces scratching frequency (30 ppm level). Relieves contact & neurodermatitis
🧴 Stabilises sensitive skin	Prevents mast cell degranulation (shown in C48/80‑induced model at 1.2% concentration)
🌿 Anti‑inflammatory	Blocks NF‑κB pathway, reduces TNF‑α and IL‑8, comparable to low‑dose hydrocortisone
💧 Barrier repair & collagen boost	Centella asiatica promotes collagen I/III synthesis, improves skin resilience
⚡ Fast sensory relief	Kava extract reduces TRPV1‑mediated stinging, burning, and pain
🧪 Non‑irritating & safe	No steroids, no known side effects; suitable for long‑term use on sensitive skin

**Technical Specifications:**
Parameter	Value
Trade name	Fuconin
INCI (principal)	Water, Centella Asiatica Root Extract, Piper Methysticum Root Extract, Scutellaria Baicalensis Root Extract, Hydroxyphenyl Propamidobenzoic Acid, Butylene Glycol, 1,2‑Hexanediol, Hydroxyacetophenone, Sodium Hydroxide
Appearance	Pale yellow clear liquid
Odor	Characteristic
Solubility	Easily soluble in water
pH	5.5 – 7.5
Stability	Stable at pH 3.0‑9.0; add at <50°C
Recommended dosage	0.5 – 3.0% (up to 5% in intensive repair formulas)
Applications	Serums, masks, creams, lotions, after‑sun gels, toners, body milks, shampoos

Proven Efficacy Data:

Mast cell degranulation inhibition (in vitro):
At 1.2% concentration, SUMER™ Fuconin significantly reduced C48/80‑induced mast cell degranulation (p<0.01), comparable to positive control cromolyn sodium (1 mg/mL).
Anti‑inflammatory / anti‑itch:
Hydroxyphenyl propamidobenzoic acid at just 30 ppm greatly reduces scratching frequency in contact and neurodermatitis models.
Collagen synthesis: Centella asiatica stimulates fibroblasts and increases collagen I/III.

Why Formulators Choose Fuconin:
✅ Multi‑mechanism – mast cell stabiliser + NF‑κB inhibitor + TRPV1 antagonist + collagen booster.
✅ Fast action – immediate relief for stinging, burning, itching.
✅ Versatile – works in leave‑on and rinse‑off products.
✅ Clean label – naturally derived ingredients, safe for sensitive skin.

Formulation Guidelines:

Dosage:
- Regular face masks: 0.3‑0.5%
- Anti‑allergy / repair masks & serums: 1‑3%
- Sensitive skin toners: 1‑1.5%
- Daily creams / gels / lotions: 0.3‑0.8%
- After‑sun care: 0.5‑1%
- Shampoos / body washes: 0.3‑0.5%
Addition: Add to water phase at <50°C during cool‑down.
pH compatibility: 3.0‑9.0 – very broad.