Hydroxypropyl Tetrahydropyran Triol (Pro-Xylane) – The High-Purity Anti-Ageing Active for GAG Synthesis & Skin Firming
Model No. : NK-2012
Brand Name: NIKOOCHEM
Place of Origin: Guangdong, China
INCI: Hydroxypropyl Tetrahydropyran Triol
Synonyms ：Pro-Xylane, C-Xyloside
CAS No.：439685-79-7
Molecular Formula：C₈H₁₆O₅
Molecular Weight：192.21 g/mol
Appearance: White to off-white crystalline powder
Odour: Slight characteristic odour
Solubility: Water-soluble
Purity: ≥98.0%
pH (1% solution) :5.0 – 8.0
Recommended dosage: 0.3% – 10.5%
Shelf Life：Sealed, cool, dry, away from light; 2-year shelf life
MOQ : 1 kg
Packaging : 1 kg/bag
Product Characteristics
A single, structurally defined C-glycoside with ≥98% purity – stimulates glycosaminoglycan synthesis, reinforces the dermal-epidermal junction, and restores skin density and elasticity.
Hydroxypropyl Tetrahydropyran Triol (INCI: Hydroxypropyl Tetrahydropyran Triol, CAS: 439685-79-7) is a high-performance anti-ageing active that has revolutionised the skincare industry. First developed as a biomimetic C-glycoside derived from xylose, this molecule has been widely recognised for its ability to stimulate the synthesis of glycosaminoglycans (GAGs) – the skin's natural water-retaining network.
With a purity of ≥98%, our Hydroxypropyl Tetrahydropyran Triol is a single, structurally defined compound produced through a rigorous chemical synthesis process. This ensures batch-to-batch consistency, high bioactivity, and reliable performance in your formulations.
How It Works
Hydroxypropyl Tetrahydropyran Triol is a C-glycoside that mimics the action of xylose, a natural sugar involved in the synthesis of proteoglycans. Once applied to the skin, it:
- Stimulates GAG Synthesis – reactivates the production of glycosaminoglycans, the water-holding molecules that plump and hydrate the skin
- Strengthens the DEJ – reinforces the dermal-epidermal junction, improving the connection between the epidermis and dermis
- Boosts Collagen Production – promotes the synthesis of collagen VII and IV, key structural proteins that maintain skin firmness and resilience
- Restores Skin Density – improves overall skin structure, reducing the appearance of fine lines and wrinkles
In a double‑blind, placebo‑controlled clinical trial (12 weeks, 5% niacinamide moisturiser, twice daily), subjects saw improvement in fine lines, wrinkles, hyperpigmentation, texture, red blotchiness, and sallowness.
6. Anti‑Inflammatory & Soothing
Niacinamide helps soothe redness, rosacea, and irritation – it reduces UVB‑induced PGE2 production by keratinocytes and decreases mast cell degranulation.
7. Antioxidant & UV Protection
Niacinamide supports DNA repair and strengthens antioxidant defences by increasing the availability of NADPH, a cofactor for the regeneration of reduced glutathione and other antioxidants. It also helps prevent UV‑induced immunosuppression
Key Benefits
|
Benefit |
Mechanism |
|
🧬 GAG Stimulation |
Rebuilds the skin's water-retaining network – restores hydration and plumpness |
|
🛡️ DEJ Reinforcement |
Strengthens the dermal-epidermal junction – improves skin density and firmness |
| ✨ Collagen Boost | Promotes collagen VII and IV synthesis – enhances skin structure |
| 💧 Deep Hydration | Restores extracellular matrix function – hydrates from within |
| ⏳ Anti-Wrinkle | Improves elasticity and reduces fine lines |
| 🌿 Synergistic |
Clinical & Market Validation
- Widely used in premium anti-ageing products globally
- Market-leading active with decades of research and clinical validation
- Proven to improve skin density, firmness, and hydration
Technical Specifications
| Parameter | Value |
| INCI Name | Hydroxypropyl Tetrahydropyran Triol |
| CAS No. | 439685-79-7 |
| Molecular Formula | C₈H₁₆O₅ |
| Molecular Weight | 192.21 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98.0% |
| pH (1% solution) | 5.0 – 8.0 |
| Solubility | Water-soluble |
| Recommended Dosage | 0.3 – 10.5% |
| Storage | Sealed, cool, dry, away from light |
| Packaging | 1 kg / bag |
| Shelf life | 24 months |
Product Application
Why Choose Our Our Hydroxypropyl Tetrahydropyran Triol?
✅ High Purity – ≥98% active content for maximum efficacy
✅ Single, Defined Structure – consistent batch-to-batch quality
✅ Clinically Proven Mechanism – stimulates GAG synthesis and collagen production
✅ Versatile – suitable for leave-on and rinse-off applications
✅ Formulator-Friendly – water-soluble, easy to incorporate
✅ Synergistic – works with retinoids, peptides, and vitamin C
Formulation Guidelines
- Dosage: 0.3 – 10.5%
- Addition: Dissolve in water phase; heat-stable, easy to incorporate
- pH: 5.0 – 8.0
- Applications:
Anti-ageing serums & creams
Firming & lifting products
Hydrating masks & essences
Skin repair & post-procedure formulas
Packaging
1kg/bag according to customers' requirements
For samples, it is shipped by express , such as FedEx,DHL,TNT& UPS, it takes around 3-7 days. For bulk order, we will recommend to ship by sea. If you have cooperated shipping agent in China , we can ship to their warehouse for you.
1, the addition amount of 1.0%-10.0% or so, it is recommended that the product is added in the formulation of low temperature (below 55 ℃ when) stage;
2、It is recommended that its package is light-avoidance closed package to reduce contact with air and light sources, sealed storage, and pay attention to reasonable sun protection.
Storage: room temperature (5-25 ℃) to save sealed, shaded cool place to save, 4-5 ℃ refrigeration is preferred. After opening, wipe the bottle clean and store it in airtight refrigerated storage, it is recommended to use it up within 1 month after opening.
Shelf life: the product can remain stable for at least two years when stored in closed containers under the recommended conditions.
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