NK‑H2008 – 5D Polysaccharide Complex | Multi‑Dimensional Moisturizing | Barrier Repair | Anti‑Itching | Microbiome Balance

A scientifically synergistic blend of five bioactive polysaccharides – engineered for next‑level hydration, soothing, and skin ecosystem health.

The 5D Polysaccharide Complex (NK‑H2008) is a revolutionary, multi‑molecular weight polysaccharide system that goes beyond conventional humectants. It combines marine, plant, microbial, and botanical sources to deliver five dimensions of skin benefits:

1. Deep, layered hydration – small molecules penetrate the stratum corneum; large molecules form a breathable, water‑retaining film.
2. Barrier reinforcement – upregulates filaggrin (FLG) and loricrin (LOR) genes; boosts ceramide synthesis.
3. Anti‑inflammatory & anti‑itching – proven to reduce histamine‑induced scratching by ~75% in vivo.
4. Microbiome modulation – promotes beneficial Staphylococcus epidermidis and inhibits pathogenic Cutibacterium acnes.
5. Powerful antioxidant protection – scavenges hydroxyl radicals and protects skin from oxidative stress.

Developed through advanced fermentation and green extraction technologies, NK‑H2008 is ideal for sensitive, dry, aging, and compromised skin – including post‑procedure and eczema‑prune conditions.

• Hydrogen bonding & electrostatic interactions – The sulfate groups in fucose and the hydroxyl‑rich polysaccharides form a stable 3D water reservoir.
  
• Molecular weight gradient – Small molecules (fucose, trehalose, xylitylglucoside) penetrate deep; large molecules (tremella polysaccharide, Euglena polysaccharide) create a surface film.
  
• Complementary gene activation – Fucose boosts lipid synthesis; oat β‑glucan activates repair genes; trehalose stabilizes the entire network.

.1，Anti‑Itching – Histamine‑Induced Scratching Model (Mouse)

• Model: Intradermal histamine injection (mice)
• Result: At just 1.0% NK‑H2008, total scratching bouts were reduced by ≈75% during the 10‑25 min observation period (p<0.05).
• Conclusion: NK‑H2008 significantly suppresses histamine‑evoked pruritus, comparable to anti‑histamine drugs.

2，Anti‑Inflammatory – LPS‑Induced RAW264.7 Macrophages

• NO reduction confirmed by Griess assay.
• ELISA confirmed IL‑6 and TNF‑α inhibition.
• No cytotoxicity – the complex alone does not induce inflammatory mediators.

3，Mast Cell Stabilization – Zebrafish Allergy Model

• Model: Tryptase expression as a marker of mast cell degranulation.
• Positive control: Cromolyn sodium (~55% reduction).
• Result: 2.0% NK‑H2008 reduced tryptase expression by ~44% (from 100% to 56.5%, p<0.05).
• Meaning: NK‑H2008 effectively inhibits allergic degranulation, preventing histamine and protease release.

4，Skin Redness Reduction – Human Facial Test (14 days)

• *a* value* represents redness (lower = less sensitive/irritated skin).
• After 14 days, the test group showed 2.67% reduction vs. 0.21% in control – indicating significant soothing and barrier improvement.

5，Skin Feel – Human Panel Test (25°C, 16 subjects)

• Interpretation: NK‑H2008 provides a lasting “plump, smooth, and calm” skin feel – not greasy, not sticky, but comfortably hydrated.

6，Barrier Repair – Gene Expression (FLG & LOR)

• FLG mRNA (filaggrin – precursor of NMF): ↑ 6.57×
• LOR mRNA (loricrin – key cornified envelope protein): ↑ 2.40×

These results confirm that NK‑H2008 actively repairs the skin barrier at the genetic level.

7，Microbiome Modulation

• Beneficial bacteria (Staphylococcus epidermidis): ↑ 2×
• Pathogenic bacteria (Staphylococcus aureus): inhibition rate 70%
• Anti‑acne effect – clear inhibition zone against Cutibacterium acnes (data on file).

8，Antioxidant – Hydroxyl Radical Scavenging

• Tremella polysaccharide alone: ~80% hydroxyl radical scavenging.
• Trehalose protects cell membranes from oxidative damage.
• Synergistic effect – MDA (lipid peroxidation marker) reduced by 40% in UV‑exposed models.

INCI Name:

Water, Glycerin, Trehalose, Euglena Gracilis Polysaccharide, Fucose, Tremella Fuciformis Polysaccharide, Avena Sativa (Oat) β‑Glucan, Xylitylglucoside, 1,2‑Hexanediol, Myrothamnus Flabellifolia Leaf/Stem Extract

Appearance:

Colorless to pale yellow, clear to slightly hazy liquid; characteristic mild odor.

pH (as supplied): 5.0 – 7.0

Solubility: Fully water‑soluble.

Compatibility: Compatible with most non‑ionic, anionic, and amphoteric surfactants; avoid strong oxidizers and high‑alcohol (>50%) systems.

Stability: Stable at pH 4.0–8.0 and temperatures up to 80°C for short periods.

Recommended dosage: 0.5 – 5.0% (optimal performance at 2.0‑5.0%).

Applications (examples):

• Soothing serums & essences
• Barrier repair creams & lotions
• Anti‑itch gels (post‑shave, eczema care)
• After‑sun / post‑procedure masks
• Moisturizing toners & mists
• Microbiome‑friendly cleansers

Note: Do not use with high concentrations of ethanol (≥50%) as it may precipitate polysaccharides.

• Listed in China IECIC 2021 – all components are allowed.
• CIR safety data: Trehalose, 1,2‑hexanediol, glycerin – safe as used.
• Preservative system – paraben‑free, phenoxyethanol‑free, formaldehyde‑free.
• Skin irritation test: Non‑irritating (primary skin irritation index = 0).
• Eye irritation test: Mildly irritating (rinse immediately if contacted).
• Photosafety: No phototoxic potential.

Allergen declaration: Does not contain common allergens (gluten, nuts, soy, dairy). Oat β‑glucan is derived from gluten‑free oats.

• Multi‑functional – replaces several single‑ingredient actives (humectant, anti‑inflammatory, barrier repair, prebiotic).
• Data‑driven – every claim supported by in‑vitro, ex‑vivo, and in‑vivo studies.
• Clean & green – natural origins, mild preservation, no ethanol required.
• Sensory excellence – non‑sticky, non‑greasy, pleasant skin feel.
• Stable & easy to formulate – water‑soluble, broad pH tolerance, heat‑stable.
• Proven consumer benefits – reduces redness, itching, and dryness; improves hydration and elasticity.