NK‑L1002 Encapsulated 4‑Butylresorcinol – Liposomal Whitening Power for Stubborn Hyperpigmentation
A high‑purity (9.5‑11.0%) 4‑butylresorcinol complex encapsulated in phospholipid liposomes – water‑soluble, stable, and deeply penetrating. Inhibits melanin at three stages, fights glycation, and protects against oxidative DNA damage.
Product Overview:
4‑Butylresorcinol is one of the most potent tyrosinase inhibitors in the resorcinol family, acting on both tyrosinase and TRP‑1 (5,6‑dihydroxyindole‑2‑carboxylic acid oxidase). It works at three critical stages of melanin formation:
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Pre‑synthesis: interferes with tyrosinase synthesis and glycosylation, preventing enzyme uptake into melanosomes.
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During synthesis: acts as a competitive inhibitor of tyrosinase and TRP‑1, reducing melanin precursors.
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Post‑synthesis: enhances tyrosinase degradation, inhibits melanosome transfer to keratinocytes, and provides exfoliation‑like effects (photopeeling) via fatty acid synergy.
However, pure 4‑butylresorcinol has poor water solubility and is easily oxidised, losing efficacy before it reaches the skin. NK‑L1002 overcomes these limitations using phospholipid liposome encapsulation – the same bilayer structure as skin cell membranes. This technology:
✅ Improves water solubility – can be used in clear serums, toners, and masks.
✅ Enhances skin penetration – liposomes fuse with the stratum corneum, delivering the active deep into the epidermis.
✅ Stabilises against oxidation – protects the active until it reaches target cells.
✅ Provides sustained release & reduces irritation – controlled delivery minimises sensitivity.
| Benefit | Mechanism |
|---|---|
| ✨ Powerful whitening & spot fading | Inhibits tyrosinase and TRP‑1 at three levels – reduces melanin synthesis and transfer |
| 🛡️ Antioxidant & DNA protection | Scavenges free radicals; protects against peroxide‑induced DNA damage |
| 🔗 Anti‑glycation | Prevents sugar‑induced collagen damage – reduces yellowing and loss of elasticity |
| ☀️ Effective against melasma & UV‑induced pigmentation | Especially useful for hyperpigmentation caused by sun exposure |
| 💧 Liposomal delivery | Water‑soluble, stable, deep penetration, low irritation |
| 🧴 Versatile | Suitable for creams, serums, masks, and water‑based clear formulas |
| Parameter | Value |
|---|---|
| Product code | NK‑L1002 |
| INCI (partial) | Butylene Glycol, 4‑Butylresorcinol, Tocopherol, Phospholipids, Polysorbate 80, Caprylic/Capric Triglyceride, Methylparaben, Water |
| Appearance | Light yellow to yellow transparent viscous liquid |
| Odour | Slight characteristic |
| pH (2% solution) | 4.5 – 6.5 |
| Active content (4‑butylresorcinol) | 9.5 – 11.0% |
| Solubility | Water‑soluble (dispersible) |
| Heavy metals | ≤10 ppm (Pb); As ≤2 ppm |
| Microbial limits | <200 cfu/ml bacteria; <100 cfu/ml yeast/mould |
| Recommended dosage | 1.0 – 10.0% (1‑3% for daily brightening; 5‑10% for intensive spot treatment) |
| Addition method | Add at <55°C (cool‑down phase) |
| Packaging | Opaque, airtight container (light/air sensitive) |
| Storage | 5‑25°C, dark, sealed; refrigeration (4‑5°C) preferred after opening |
| Shelf life | 2 years unopened |
Why Formulators Choose NK‑L1002:
✅ One of the strongest tyrosinase inhibitors – more effective than many resorcinol derivatives.
✅ Triple‑stage melanin blockade – unique among whitening agents.
✅ Encapsulated for stability & penetration – no special solvents, easy to formulate in water‑based systems.
✅ Anti‑glycation & DNA protection – extra anti‑aging benefits.
✅ Synergistic formula – includes tocopherol and phospholipids for added antioxidant effect.
Formulation Guidelines:
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Dosage: 1 – 10% (2‑3% for general whitening; 5‑10% for intensive spot correction).
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Addition: Add to water phase at <55°C (cool‑down). Avoid high heat.
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Packaging: Use opaque, airtight packaging (airless pump, aluminium tube) to prevent oxidation.
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Applications:
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Whitening serums & ampoules
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Brightening toners & masks
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Melasma / hyperpigmentation creams
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Anti‑aging formulas (combined with antioxidants)
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