NK‑L1013 liposome‑encapsulated blend of 4‑butylresorcinol (30%) – The Complete Liposomal Whitening Complex for Superior Brightening & Formulation Stability
INCI No. : 4‑Butylresorcinol、3‑O‑Ethyl Ascorbic Acid (VC Ethyl Ether)、Phospholipids、Tocophersolan (Vitamin E derivative)、Sodium Metabisulfite
Place of Origin: Guangdong, China
Applications:
- Whitening & brightening creams and lotions
- Dark spot correctors and melasma treatments
- Brightening serums and essences
- Post‑inflammatory hyperpigmentation treatments
Product Names: NK-L1013 Nanoencapsulated 4-butylresorcinol
Appearance: Light yellow to yellow transparent viscous liquid
Brand Name: NIKOO
Model Number: NK-L1013
Grade: Comestic Grade
Packaging Details: 1kg/bottle, 10kg/can
Product Characteristics
A synergistic, liposome‑encapsulated blend of 4‑butylresorcinol (30%) and 3‑O‑ethyl ascorbic acid (2%) – the most potent resorcinol derivative combined with a stable vitamin C derivative. Delivers triple‑stage melanin inhibition, powerful antioxidant protection, and enhanced formulation compatibility for creams, serums, and emulsions.
NK‑L1013 Youyifu is a next‑generation, liposome‑encapsulated whitening complex specifically developed to overcome the formulation challenges of 4‑butylresorcinol – one of the most potent tyrosinase inhibitors available.
4‑Butylresorcinol (also known as Rucinol) is a highly effective skin brightener, capable of inhibiting tyrosinase and TRP‑1 at three critical stages of melanin formation:
Pre‑synthesis: Interferes with tyrosinase synthesis and glycosylation, preventing enzyme uptake into melanosomes.
During synthesis: Competitively inhibits tyrosinase and TRP‑1, reducing melanin precursors.
Post‑synthesis: Enhances tyrosinase degradation, inhibits melanosome transfer to keratinocytes, and provides exfoliation‑like effects via fatty acid synergy.
However, pure 4‑butylresorcinol is highly polar and ionic, making it notoriously difficult to formulate in emulsion systems – often causing demulsification, separation, and oil‑layer breakout. It is also easily oxidised and loses efficacy before reaching the skin.
NK‑L1013 solves these challenges with advanced phospholipid liposome technology:
✅ Enhanced emulsification compatibility – the liposomal structure integrates seamlessly into creams, lotions, and emulsions, preventing demulsification and simplifying formulation design.
✅ Improved water solubility – enables use in transparent serums, toners, and masks.
✅ Superior skin penetration – liposomes fuse with the stratum corneum, delivering actives deep into the epidermis.
✅ Stability against oxidation – liposomal protection preserves active integrity until it reaches target cells.
✅ Sustained release & reduced irritation – controlled delivery minimises skin sensitivity.
Key Ingredients & Their Synergy
|
Component |
Concentration |
Function |
|
4‑Butylresorcinol |
30% | One of the most potent tyrosinase inhibitors; triple‑stage melanin blockade |
|
3‑O‑Ethyl Ascorbic Acid (VC Ethyl Ether) |
2% | Stable, water‑ and oil‑soluble vitamin C derivative; inhibits tyrosinase, provides antioxidant protection, and brightens |
|
Phospholipids |
5% | Liposome carrier; enhances skin penetration and bioavailability |
|
Tocophersolan (Vitamin E derivative) |
5% | Potent antioxidant; protects formulation from oxidation |
|
Sodium Metabisulfite |
0.2% | Antioxidant stabiliser; prevents active degradation |
Together, these components create a multifaceted whitening system:
- 4‑butylresorcinol blocks melanin production at the source
- 3‑O‑ethyl ascorbic acid reduces existing pigmentation and provides antioxidant defence
- Liposomal delivery ensures both actives reach their targets efficiently
Key Benefits at a Glance
| Benefit | Mechanism |
| ✨ Powerful whitening & spot fading | 4‑butylresorcinol inhibits tyrosinase and TRP‑1 at three levels – reduces melanin synthesis and transfer |
| 🛡️ Antioxidant & DNA protection | 3‑O‑ethyl ascorbic acid scavenges free radicals; protects against peroxide‑induced DNA damage |
| 🔗 Anti‑glycation | Prevents sugar‑induced collagen damage – reduces yellowing and loss of elasticity |
| ☀️ Effective against melasma & UV‑induced pigmentation | Especially useful for hyperpigmentation caused by sun exposure |
| 💧 Liposomal delivery | Water‑soluble, stable, deep penetration, low irritation |
| 🧴 Formulation‑friendly | Compatible with emulsions, creams, serums, and masks – no demulsification |
Clinical & Market Validation
- Superior potency: 4‑butylresorcinol is more potent than hydroquinone, kojic acid, or arbutin in published tyrosinase inhibition assays.
- Faster results: 4‑butylresorcinol significantly reduced age spots within 8 weeks, while other resorcinol derivatives required 12 weeks.
- Clinically proven safety: Clinical trials have demonstrated the efficacy and safety of 4‑butylresorcinol in treating melasma at concentrations of 0.1% and 0.3%.
- Regulated approval: 3‑O‑ethyl ascorbic acid is a globally recognised, stable vitamin C derivative widely used in skincare for its potent antioxidant, brightening, and anti‑aging properties
Technical Specifications
| Parameter | Value |
| Product code | NK‑L1013 |
| Active content (4‑butylresorcinol) | 29.0 – 31.0% |
| 3‑O‑Ethyl Ascorbic Acid content | 1.0 – 3.0% |
| Appearance | Light yellow to yellow transparent viscous liquid |
| Odour | Slightly characteristic |
| pH (2% solution) | 4.5 – 7.5 (typical 6.15) |
| Solubility | Water‑soluble (dispersible) |
| Heavy metals | Pb <10 ppm, As <2 ppm, Hg <1 ppm, Cd <5 ppm |
| Bacterial count | <200 cfu/ml |
| Mould & yeast | <100 cfu/ml |
| Pathogens | Not detected |
| Recommended dosage | 1.0 – 6.0% (leave‑on); 0.5 – 5.0% (rinse‑off) |
| Addition method | Add at <55°C (cool‑down phase) |
| Packaging | Opaque, airtight container (light/air sensitive) |
| Storage | 5‑30°C, dark, sealed; refrigeration (5‑15°C) preferred after opening |
| Shelf life | 12 months unopened |
Risk Substance Compliance:
- Phenol: not detected (<2.0 ppm limit)
- Resorcinol: compliant (<10.0 ppm limit)
- Dioxane: not detected (<30 mg/kg limit)
- Diethylene glycol: not detected (<200 mg/kg limit)
Product Application
Why Formulators Choose ULA‑L1013
✅ The most potent whitening active – 4‑butylresorcinol outperforms hydroquinone, kojic acid, and arbutin
✅ Triple‑stage melanin blockade – acts before, during, and after melanin synthesis
✅ Synergistic formula – 4‑butylresorcinol + 3‑O‑ethyl ascorbic acid + vitamin E for comprehensive brightening and antioxidant protection
✅ Liposomal delivery – water‑soluble, stable, deep penetration, low irritation
✅ Formulation‑friendly – compatible with creams, serums, masks, and emulsions
Formulation Guidelines
- Dosage: 1.0 – 6.0% (2‑3% for daily brightening; 4‑6% for intensive spot treatment)
- Addition: Add to water phase during cool‑down (<55°C). For emulsions, add after emulsification to preserve liposome integrity.
- pH: 4.5 – 7.5 (optimal 5.0 – 6.5)
- Packaging: Use opaque, airtight packaging (airless pump, aluminium tube) to prevent oxidation.
- Applications:
- Whitening & brightening creams and lotions
- Dark spot correctors and melasma treatments
- Brightening serums and essences
- Post‑inflammatory hyperpigmentation treatments
NK‑L1013 – The complete liposomal whitening complex for superior brightening and formulation stability.
Packaging
1kg/bottle, 10kg/tank according to customers' requirements
For samples, it is shipped by express , such as FedEx,DHL,TNT& UPS, it takes around 3-7 days. For bulk order, we will recommend to ship by sea. If you have cooperated shipping agent in China , we can ship to their warehouse for you.
1, the addition amount of 1.0%-10.0% or so, it is recommended that the product is added in the formulation of low temperature (below 55 ℃ when) stage;
2、It is recommended that its package is light-avoidance closed package to reduce contact with air and light sources, sealed storage, and pay attention to reasonable sun protection.
Storage: room temperature (5-25 ℃) to save sealed, shaded cool place to save, 4-5 ℃ refrigeration is preferred. After opening, wipe the bottle clean and store it in airtight refrigerated storage, it is recommended to use it up within 1 month after opening.
Shelf life: the product can remain stable for at least two years when stored in closed containers under the recommended conditions.
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