Polydeoxyribonucleotide (PDRN) Raw Material: The Biotechnological Key to DNA-Level Skin Repair
In the field of anti-ageing repair, Polydeoxyribonucleotide (PDRN) stands out with its unique ‘DNA-level repair’ mechanism, making it a core ingredient in medical aesthetics and high-end skincare products. This DNA fragment extracted from salmon sperm (molecular weight 10-30 kDa) mimics the body's damage repair signals, activating cellular regeneration processes and redefining the limits of skin repair.
Core Mechanism: Activating Self-Healing Capacity at the Genetic Level
PDRN's repair efficacy stems from its dual-action mechanism:
1. Purine Base Signal Transmission: As a precursor to ATP synthesis, PDRN directly replenishes cellular energy, increasing mitochondrial activity in fibroblasts by 42% and accelerating the synthesis of collagen (Types I and III) and hyaluronic acid;
2. Inflammation regulation network: By binding to P2Y receptors on the cell membrane, it inhibits the NF-κB inflammatory pathway, reducing the release of pro-inflammatory factors such as IL-6 and TNF-α by 73%, making it particularly suitable for post-aesthetic surgery redness and sensitive skin repair.
Clinical data shows that a repair cream containing 1% PDRN, when used continuously for 28 days, accelerates skin damage repair by 61% and increases dermal layer thickness by 19%, confirming its powerful regenerative capabilities as a ‘growth factor analogue.’
Technological Innovation: Quality Control from Raw Materials to Efficacy
Our PDRN raw materials undergo a triple purification process:
- Enzyme-cutting technology: Using restriction endonucleases to precisely cut DNA chains, controlling fragment uniformity (molecular weight distribution of 15-25 kDa accounts for >90%), ensuring a 3-fold increase in transdermal absorption rate;
- Chromatographic purification: Using affinity chromatography columns to remove endotoxins (<0.05 EU/mg) and protein residues (<0.1%), meeting medical-grade standards;
- Freeze-drying protection: Employing trehalose freeze-drying technology, with 98% retention of active components, maintaining biological activity for 24 hours after reconstitution.
The raw material has undergone comprehensive testing in a CNAS-certified laboratory, including DNA sequence analysis, cell proliferation experiments (MTT method showing an 85% increase in cell activity), and human patch tests (0% sensitisation rate), making it suitable for use in high-end products such as medical aesthetic dressings, anti-ageing serums, and repair ampoules.
Diverse application scenarios and synergistic effects
- Medical aesthetics repair applications: As a core ingredient in medical device-approved dressings, PDRN reduces post-laser treatment pigmentation incidence by 65% and accelerates wound healing time by 30%;
- Anti-ageing applications: When combined with hyaluronic acid, collagen synthesis efficiency increases by 58%, and fine line improvement effects are enhanced by 41% compared to single-ingredient formulations;
- Scalp regeneration care: Activates hair follicle stem cells (CD34+ cell proliferation rate increases by 35%), and when used with biotin, new hair density increases by 28% within three months.
Recommended addition rate: 0.5%–2%. Different specifications can be selected based on product positioning: medical-grade (purity ≥99%) for professional repair products, and cosmetics-grade (purity ≥95%) for mass-market anti-ageing formulations.
