Skin Bolt Collagen | Recombinant Humanised Type XVII Collagen
What is Type XVII Collagen？
Collagen Type XVII is a signaling protein with a key structure that improves skin texture by repairing the basement membrane bands through a unique signaling modulation for ‘cellular self-cleansing’ (the epidermis automatically removes senescent cells).
Why supplement with XVII collagen?
1. Enhance skin firmness: Strengthen skin structure and improve skin laxity.
2. Reduces wrinkles: replenishes collagen and repairs broken collagen fibres.
3. Improve skin tone: Promote skin health, reduce pigmentation and brighten skin tone.
4. Enhance the skin barrier: improve the skin's self-protection ability, defence against external environmental aggression.
In recent years, authoritative academic results have pointed out that XVII collagen is a key factor in cell regeneration and repair, which plays an important role in resisting skin aging, controlling hair loss and grey hair, and promoting wound repair.
Recombinant Humanised Type XVII Collagen
Strong anti-wrinkle, base-tightening type XVII active collagen
Anti-wrinkle & Firming / Substrate Repair / Sensitivity Improvement
Mechanism of action of type XVII collagen
Adult stem cells (ASC) are essential for cell replacement in tissues and their main function is to replace cells that may have died due to disease or injury and to maintain a state of homeostasis within the cell, but their ability to do so declines with age.
Human skin contains a variety of stem cells, including epidermal stem cells, hair follicle stem cells, and melanocyte stem cells, which are key to regulating the skin's aging process and have been called the skin's ‘fountain of youth’.
Research has shown that XVII collagen helps stem cells maintain their ecological niche and function by mediating the interaction between stem cells and surrounding cells and matrices, thus harmonising skin homeostasis, promoting epidermal regeneration and activating hair growth.
A 2019 study published in Nature reveals that type XVII collagen fights skin aging by driving cellular competition, allowing stem cells with higher quality to win out and eliminate damaged or unhealthy cells.
The article notes that type XVII collagen decreases over time, which is one of the major factors in skin aging, and that if XVII collagen levels are maintained, the skin aging process can be rescued.
Another paper published in Science shows that hair follicle stem cells play a key role in hair regeneration, while the loss of hydrolysis of type XVII collagen is one of the causes of aging of hair follicle stem cells, and by maintaining the level of type XVII collagen, the aging of hair follicle stem cells can be resisted to alleviate the symptoms of hair loss.
In wound repair, type XVII collagen accelerates wound healing by influencing stem cell population dynamics and regulating stem cell migration and proliferation.
Wide range of application scenarios and high market growth
Due to its effects of resisting skin aging, maintaining skin structural integrity and elasticity, promoting wound healing, and participating in the growth of hair follicles, type XVII collagen is increasingly used in personal care, medical cosmetology, biomaterials, hair regeneration, and other fields.
Skin care products: Type XVII collagen is expected to further enhance the anti-aging and moisturising effects of cosmetics. By lowering the molecular weight of collagen, it can help to better penetrate into the skin and achieve the goals of maintaining tissue homeostasis and resisting the aging process.
The market size of efficacious skin care products based on recombinant collagen will be RMB 4.6 billion in 2021 and is expected to reach RMB 64.5 billion in 2027, with a CAGR of 52%.
Medical beauty: different from type I, type III collagen acts in the dermis, XVII collagen acts in the epidermal basal layer, for the basement membrane has a safeguard repair effect, and more can promote the secretion of type I, type III collagen, so it is often used to amplify the advantages by association.
