Type III Recombinant Human Collagen Protein — A Biological Shield for Anti-Aging in Sensitive Skin
The anti-ageing challenge for sensitive skin fundamentally stems from the complete breakdown of the skin barrier function. Recombinant Type III human collagen protein leverages dual mechanisms of biomimetic repair and immune regulation to provide a systematic solution for sensitive skin.
Type III collagen is the primary collagen type in infant skin, accounting for up to 80% of its composition. Its fine fibre structure confers elasticity and repair capabilities to the skin. As we age, the content of Type III collagen in adult skin plummets to 20%, and fibroblasts lose their ability to synthesise it, leading to weakened barrier function and exacerbated inflammatory responses. Recombinant Type III human collagen protein replicates the core functional regions of human Type III collagen through genetic engineering technology, directly supplementing missing collagen fibres and reconstructing the dermal network structure.
In terms of physical barrier repair, the nanoscale fibre network formed by recombinant type III collagen mimics intercellular lipids, reducing transepidermal water loss (TEWL) from 45 g/(m²·h) to 18 g/(m²·h) while increasing ceramide content to 85%. Clinical studies show that after six weeks of using a repair cream containing 0.1% recombinant type III collagen, the erythema index for sensitive skin improved from 15 to 85, with a recurrence rate of only 7%.
Immune regulation is another major advantage of recombinant type III collagen. Its degradation fragments competitively inhibit the IL-31 receptor, reducing itch scores from 7.2 to 2.1; simultaneously, they downregulate MyD88 protein expression, reducing inflammatory factor release by 70%. This intelligent anti-inflammatory system is particularly suitable for complex sensitive issues such as rosacea and hormone-dependent dermatitis. In a typical case, the patient's collagen density increased from 29 μg/mm³ to 61 μg/mm³, and the frequency of flushing decreased from 6 times per day to 0.5 times per day.
Our recombinant human type III collagen uses liposome encapsulation technology, enhancing transdermal absorption by 3 times, with pH precisely controlled at 5.5 ± 0.2, highly compatible with healthy skin conditions. Whether for post-aesthetic surgery repair dressings or daily sensitive skin care products, our raw materials are certified under the ISO 13485 medical device quality management system, providing brands with safe and reliable technical support.
