Anti Aging Repair Magic - Fibronectin

Fibronectin, also known as fibronectin, English name fibronectin (abbreviation FN), is a macromolecular glycoprotein discovered in 1974 by foreign research with various biological functions.FN is widely found in animal tissues and tissue fluids, and is a macromolecular glycoprotein with a molecular weight of about 450 KD, with a variety of biological activities. It can activate and regenerate the repair of senescent and damaged cells, and plays a key role in both the nuclear reprogramming process of senescent cells and in mediating cellular vesicle transport. Therefore, FN is internationally recognised as an ‘anti-aging protein’ by the life science community.

What exactly is fibronectin?

Fibronectin, a macromolecular extracellular membrane protein present on the cell surface of many animal species, is the major non-collagenous glycoprotein in the extracellular matrix and basement membrane.

A large number of studies and clinical applications have proved that fibronectin is a key substance in promoting wound healing.

In recent years, there have been numerous products on fibronectin, and the products are so dazzling that people don't know how to choose, today we will talk about why fibronectin is so favoured? How does fibronectin repair wounds?

Is fibronectin equal to collagen?

What makes fibronectin so popular?

Compared with the familiar collagen, fibronectin has a relatively large molecular weight, and a relatively large number of structural domains and structural sites, so it also plays a stronger role in the human body.

Fibronectin can repair cells, deep into the epidermis, dermis and subcutaneous tissue, stimulate the three layers of cellular prime mover, enhance the skin cell metabolism function, promote cell growth, fundamentally solve the various problems of the cells, to restore the youthful state of the cells, the healing of the living problem muscle, resistance to aging.

How does fibronectin repair wounds?

Fibronectin is very important in beauty, known as the repair expert, mainly for: dry peeling, acne, collagen loss and breakage, sagging, sensitive skin, red blood line, after-sun repair, hormone face, skin damage after medical art.

Simply put, Fibronectin can repair all wounds, widely used for fresh wounds (plastic surgery, minimally invasive, microneedle, post-laser surgery, etc.) burn wounds and chronic hard-to-heal wounds (post-operative non-healing, etc.).

Is fibronectin equal to collagen?

Fibronectin and collagen are two different proteins, collagen is just a filler, is a filler, and fibronectin own skin cells to produce collagen, so as to restore the elasticity of the skin.

Fibronectin can repair all layers of skin cells, so that their own skin to produce a variety of moisturising factors, thereby mobilising their own water from the inside out to moisturise the skin, as if to open up their own skin water source.

Fibronectin As a non-collagenous glycoprotein prevalent in the extracellular matrix, there are more than 20 kinds of fibronectin in the human body, which are widely present in the blood, body fluids and various tissues, and it is not only a regulating factor in the process of cellular activity, but also an important scaffolding protein that maintains and guides the composition of tissue structure and extracellular matrix.

Normally, fibronectin is very ‘low profile’, but when we are injured, fibronectin starts to ‘work in high profile’.

In the early coagulation phase of trauma, fibronectin is released from platelets and deposited on damaged collagen and fibronectin, enhancing platelet adhesion, phagocytosis and fibroblast migration and cell proliferation, and activating neutrophils, enhancing their adhesion and accelerating their aggregation to the traumatised area.

In the middle stage of trauma repair, fibronectin is an important chemokine for fibroblasts that enhances cell adhesion and chemotaxis by helping to maintain cytoskeletal structure. When fibronectin cross-links with fibronectin and adheres to the blood clot, it helps to direct fibroblasts rapidly into the trauma area.

Fibroblasts entering the traumatised area spin a fibrous web, which is the beginning of the healing process, and then collagen, acetylheparin sulphate, proteoglycans, chondroitin sulphate and other extracellular matrix components are deposited on this web. In this way, over time, the damaged area is ‘filled in’.

Finally, fibronectin helps to reorganise our subepidermal basement membranes and ensures that keratinisation takes place properly.

In addition, some researchers have deduced from the experimental results that fibronectin may also have a restorative effect on radiation-induced skin damage, and that exogenous supplementation of fibronectin may be helpful in the repair of radiation-damaged tissues.

Simply put, in skin wound repair and healing, fibronectin can shorten wound healing time and reduce wound scarring, and thus is widely used in regenerative medicine. In skin care, fibronectin's restorative effect is to promote the normal physiological metabolism of the skin, smoothing out fine lines and slowing down the aging process, while preventing the abnormal secretion of melanin cells, i.e., whitening, lightening and other effects.