Anti-Aging Skin Repair Facial Essence Hydrating Cosmetic High Purity Recombinant Humanized Type I Collagen lyophilized powder
INCI No. : WATER、MANNITOL、TREHALOSE、COLLAGEN
Place of Origin: Guangdong, China
Usage: Plumping and anti-aging, Reducing wrinkles and rejuvenating skin, Repairing damage, Promoting collagen production
Product Names: Recombinant Humanized Type I Collagen
Appearance:White to off-white Solid
Brand Name: NIKOO
Model Number: Recombinant Humanized Type I Collagen
Grade: Comestic Grade
Packaging Details: 100g/bag
Product Characteristics
This recombinant human collagen type I (COL1A1)/ COL1 is available as full-chain or single chain molecules. Its synthesis and assembly require a multitude of genes and post-translational modifications which gives a more native human structure. The triple-helical collagens made by recombinant technology have the same amino acid sequence as human tissue-derived collagen. Furthermore, by achieving the equivalent extent of proline hydroxylation via co-expression of genes encoding prolyl hydroxylase with the collagen genes, one can produce collagens with a similar degree of stability as naturally occurring material.
Human Recombinant Collagen Type I is a bioengineered fibrillar collagen produced through microbial expression systems (e.g., E. coli). As the most abundant collagen in human skin and bones, it provides structural support and tensile strength. Ideal for anti-aging skincare and bone tissue engineering. Typically provided as lyophilized powder with ≥90% purity (SDS-PAGE verified).
COLl recombinant type l collagen is a geneticallyengineered human recombinant collagen.
Compared with collagen extracted from animals, it has lowimmunogenicity, high biocompatibility, high bioavailability, is easierto penetrate the skin barrier and is conducive to absorption.
It stimulates the metabolic process of cells and induces the growthproliferation and migration of skin cells, thereby deeply promotingskin barrier repair and wrinkle removal and anti-aging.
Product Specification
|
Item |
Specification |
|
Product Grade |
Molecular biology grade, sterile lyophilized powder |
|
Product Names |
Recombinant Humanized Type I Collagen |
|
CAS Number |
9064-67-9 |
| Source Species | Microbial |
| Gene Source | Human |
| Product Specifications | 10g/bottle, 100g/bottle, etc. (customizable to kilogram-scale) |
| PI (Isoelectric Point) | 6.59 |
| PH Value(10% aqueous solution, 25℃) | 5-8 |
| Electrophoretic Purity | >95% (SDS-PAGE) |
| Protein Content | >90% |
| Dry Weight Loss | <10% |
| Thermal Stability | No foreign substances generated |
| Bacterial Endotoxin | <0.5EU/mg |
| Microorganisms | <5cfu/g |
|
Residual Heavy Metals
|
≥13% |
| Total bacterial cfu/g | <10ppm |
| Solubility/Water Solubility | Easily soluble in water |
| Shelf Life | Store at -20°C in a dry environment for at least 1 year after receipt |
|
Applications |
Collagen is an abundant protein in the human body, crucial for maintaining normal physiological functions. Recombinant humanized collagen, due to its excellent physical properties and biological characteristics, has widespread applications in pharmaceuticals, tissue engineering, food, cosmetics, and other fields. |
Product Application
Type I collagen is the most abundant collagen in the human body, widely distributed in the matrix in vitro, mainly in the skin, bones, tendons and connective tissues, with a high degree of toughness and tensile strength, so once the loss of type I collagen will appear facial wrinkles and depression. Type I collagen also has a wide range of applications in medicine, cosmetics and other fields:
√ Skin care effects: it can increase skin elasticity, improve skin moisture and moisturizing, and maintain skin youthfulness;
√ Mechanical support: widely used to construct biological scaffolds to promote tissue regeneration, such as skin, cartilage and bone repair
√ Transportation function: signaling, transport of growth factors and cytokines;
√ Biomarker: as a surrogate marker for bone degradation and formation to help physicians better understand the pathophysiology of disease;
The development of recombinant collagen began in the late 1920s. Unlike animal-derived collagen and humanoid collagen, recombinant human collagen can be simply and roughly understood as collagen of a higher order of technical difficulty and safety. While collagen extracted from animal tissues may contain impurities and vary from batch to batch, collagen produced through genetic engineering technology has a high degree of purity and a controlled production process, while avoiding the risk of animal-derived contamination and reducing the likelihood of allergic and immune rejection reactions.
NIKOO recombinant humanized type I collagen, derived from microorganisms, is characterized by low impurities and high purity, effectively reducing the risk of allergy. With excellent hydrophilicity and moisturizing properties, it deeply moisturizes the skin and maintains a long-lasting sense of hydration. It can be applied to the face, eye area, neck and other parts of the body. It can improve the skin barrier, inhibit tyrosinase and slow down melanin deposition; lock water and moisturize the skin to prevent the formation of dry lines; enhance the skin's immune function and improve the skin's micro-ecology and other effects.
The use of advanced protein engineering technology and a 28,000 liter yeast platform not only dramatically reduces unit cost, but also improves production efficiency and product quality, enabling us to provide our customers with the best cost-effective recombinant humanized collagen.
Packaging
100g/bag according to customers' requirements
For samples, it is shipped by express , such as FedEx,DHL,TNT& UPS, it takes around 3-7 days. For bulk order, we will recommend to ship by sea. If you have cooperated shipping agent in China , we can ship to their warehouse for you.
If used for pure type III collagen lyophilized powder recommended additive amount: 10-50%, other types such as emulsions, creams, sprays and other products recommended additive amount: 0.1-5%.
It is recommended that its package is light-avoidance closed package to reduce contact with air and light sources, sealed storage, and pay attention to reasonable sun protection.
Storage: room temperature (5-25 ℃) to save sealed, shaded cool place to save, 4-5 ℃ refrigeration is preferred. After opening, wipe the bottle clean and store it in airtight refrigerated storage, it is recommended to use it up within 1 month after opening.
Shelf life: the product can remain stable for at least two years when stored in closed containers under the recommended conditions.
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