Best Recombinant Collagen Serum Formulation
Recombinant Collagen Serum Formulation
Base Formula (Water-Based Serum):
Phase A (Aqueous Phase) – 90%
| Ingredient | Percentage | Function |
|---|---|---|
| Recombinant Human Collagen (Type I/III) | 3-5% | Stimulates fibroblast activity, improves elasticity, repairs skin structure |
| Glycerin | 5% | Humectant for hydration |
| Niacinamide | 5% | Brightens, strengthens barrier, boosts collagen synthesis |
| Sodium Hyaluronate (Low & High MW) | 2% | Multi-depth hydration & plumping |
| Panthenol (Vitamin B5) | 2% | Soothes, hydrates, supports healing |
| Allantoin | 0.5% | Calms irritation, promotes repair |
| Ethylhexylglycerin + Phenoxyethanol (Preservative) | 1% | Preservative system |
Phase B (Penetration & Stability Enhancers) – 8%
| Ingredient | Percentage | Function |
|---|---|---|
| Propanediol (or Butylene Glycol) | 5% | Enhances collagen penetration, solubilizer |
| Ethoxydiglycol (Transcutol P) | 2% | Boosts actives' absorption |
| Xanthan Gum (or Carbomer) | 0.5% | Thickener for texture |
| Citric Acid / Sodium Citrate | q.s. | pH adjuster (~5.5-6.0) |
Phase C (Antioxidants & Peptides) – 2%
| Ingredient | Percentage | Function |
|---|---|---|
| Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7) | 1% | Boosts collagen, reduces wrinkles |
| Vitamin E (Tocopherol) | 0.5% | Antioxidant, prevents collagen degradation |
| Ferulic Acid | 0.5% | Stabilizes, enhances antioxidant defense |
Key Benefits:
✅ Stimulates natural collagen (via recombinant collagen + peptides)
✅ Deep hydration (hyaluronic acid + glycerin)
✅ Strengthens skin barrier (niacinamide + panthenol)
✅ Antioxidant protection (vitamin E + ferulic acid)
✅ Improved penetration (ethoxydiglycol + propanediol)
Manufacturing Process:
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Dissolve Phase A in water (heat to 70°C if needed).
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Mix Phase B separately, then combine with Phase A.
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Adjust pH to 5.5-6.0 (optimal for collagen stability).
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Cool to 40°C, add Phase C (heat-sensitive actives).
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Homogenize and fill into airless pump bottles (prevents oxidation).
Why Recombinant Collagen?
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Bioidentical to human collagen (better than animal-derived).
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Non-immunogenic (lower risk of irritation).
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Sustainable & vegan-friendly.
Recommended Suppliers:
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Recombinant Collagen: Geltor (HumaColl21™), CJ Bioscience (CJ-8000)
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Peptides: Sederma (Matrixyl), Lucas Meyer (Peptilium)
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Hyaluronic Acid: Bloomage Biotech, Evonik
This formulation is clinically effective, stable, and luxe-feeling while being scalable for production. Would you like adjustments for a specific skin concern (e.g., sensitive skin, acne-prone)?
