CERAMIDE NP - Premium Skin Barrier Repair Active Ingredient

Pharmaceutical-Grade Ceramide for Advanced Skincare Formulations

Our CERAMIDE NP (also known as Ceramide 3) is a high-purity, bioactive lipid molecule that replicates the identical ceramide structure naturally found in human skin. As a crucial component of the skin's barrier system, CERAMIDE NP constitutes approximately 50% of the intercellular lipid matrix in the stratum corneum, making it essential for effective barrier repair and moisturization solutions in skincare formulations .

This sophisticated raw material is manufactured using proprietary synthetic biology processes that ensure exceptional purity (≥95%) and batch-to-bonsistency. Our CERAMIDE NP is specifically engineered to address the challenges of dryness, sensitivity, aging, and barrier compromise in skincare products, offering formulators a powerful active ingredient with clinically demonstrated efficacy across multiple skin parameters .

With its unique combination of plant-derived phytosphingosine base and stearic acid (representing the "N" and "P" designations respectively), our CERAMIDE NP provides exceptional compatibility with skin lipids, enabling seamless integration into the skin's natural architecture for enhanced barrier restoration and long-lasting hydration

Ceramides are naturally occurring lipids in the skin that form a waterproof barrier on the skin's surface, better protecting it and leaving it moisturized and soft. Ceramide 3, derived from bio-fermentation, is a new generation of skin moisturizer developed in recent years. It maintains skin hydration, repairs dry and damaged skin, and promotes the renewal of the skin's natural protective layer. Currently, it is widely used in skincare cosmetics as an effective active ingredient.

A crucial prerequisite for achieving skincare efficacy is the effective penetration of active ingredients into the skin's surface, resulting in high concentrations and prolonged retention in skin tissue—that is, targeted delivery of active ingredients. Currently, most commercially available ceramide cosmetics are in the form of ordinary creams, with poor skin permeability and low retention of active ingredients. Furthermore, ceramide 3 is a highly crystalline substance, exhibiting poor dispersibility and extremely low solubility in water and most oils, making it prone to crystallization during storage, which is detrimental to the absorption of active ingredients and product stability.

The stratum corneum of human skin has a strong barrier function, making it difficult for large-molecule functional substances to penetrate. Liposomes, with their double-membrane structure similar to the biological cell membrane structure of the skin, have high biocompatibility with the skin and are more easily absorbed by cell membranes, making them readily absorbed and penetrated on the skin epidermis.

NK-L1004 encapsulated ceramides are produced by NIKOO using phospholipid liposome encapsulation technology. Using phospholipids as a carrier, ceramide 3, which is poorly soluble in oils, esters, and water, is encapsulated within liposomes. A special process is then used to create a transparent microemulsion of phospholipid ceramide liposomes with a particle size of 100-200 nanometers. This allows the encapsulated ceramides to be directly applied to water-based products and remains stable without precipitation. Furthermore, the ceramides carried by nano-phospholipid liposomes are more easily penetrated and absorbed on the skin epidermis.

Our CERAMIDE NP is manufactured through a revolutionary synthetic biology approach that combines precision fermentation with advanced purification technologies:

1. Strain Development & Optimization: We utilize proprietary microbial strains specifically engineered for high-yield production of ceramide precursors. These strains are developed through gene site analysis and saturation site construction, followed by high-throughput screening using our proprietary Qiji platform to identify optimal production strains .
   
2. Precision Fermentation: The selected strains undergo controlled fermentation in state-of-the-art bioreactors using glucose and amino acids as primary substrates. This aerobic fermentation process enables the direct production of ceramide precursors through biological transformation, significantly reducing the need for chemical synthesis steps .
   
3. Downstream Processing & Purification: After fermentation, the crude product undergoes multi-stage extraction and purification using specialized solvent systems and chromatographic techniques. This process ensures the removal of impurities while maintaining the structural integrity of the ceramide molecules
   
4. Quality Enhancement: The purified ceramide undergoes a proprietary maturation process that enhances stability and ensures consistent performance in final formulations. This includes precise control of crystal structure to prevent phase transitions that could compromise functionality .
   
5. Comprehensive Quality Control: Each batch undergoes rigorous analytical testing including HPLC for purity assessment, GC-MS for contaminant screening, and stability testing under various conditions to ensure compliance with stringent quality standards

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As a leading manufacturer of bioactive skincare ingredients, we offer distinct advantages that make us the preferred partner for skincare brands worldwide:

• Proprietary Synthesis Technology: Our advanced synthetic biology platform enables direct production of CERAMIDE NP through single-step fermentation, eliminating the need for multi-step chemical processes and ensuring higher purity and better sustainability .
  
• Recognized Quality Standards: Our manufacturing facilities adhere to ISO 9001, GMP standards, and our products are IFRA compliant, and meet international regulatory requirements for cosmetic ingredients .
  
• Scalable Production Capacity: With annual production capacity of 10,000+ tons and fully automated production lines, we can reliably supply both small development quantities and large commercial volumes with consistent quality .
  
• Sustainability Commitment: Our production processes incorporate green chemistry principles, solvent recycling systems, and water conservation measures to minimize environmental impact 

Our CERAMIDE NP offers exceptional performance characteristics that make it ideal for advanced skincare formulations:

Superior Barrier Repair

CERAMIDE NP effectively restores the skin's natural barrier function by replenishing essential lipids in the stratum corneum. Clinical studies demonstrate significant improvement in skin barrier integrity with reduction in transepidermal water loss (TEWL) by up to 30% after 14 days of use at 2% concentration .

Enhanced Hydration

The molecule's unique structure allows it to form an effective barrier against moisture loss while holding water molecules through hydrogen bonding. Formulations containing our CERAMIDE NP show up to 50% immediate improvement in stratum corneum hydration and 33.77% sustained improvement after 14 days of use

Anti-Aging Benefits

Beyond barrier function, CERAMIDE NP demonstrates significant anti-aging properties. At 0.5% concentration, it reduces crow's feet wrinkle area by approximately 1%, while at 5% concentration, it delivers up to 6% improvement in wrinkle area after 60 minutes of application

Soothing & Anti-Inflammatory Effects

CERAMIDE NP significantly reduces skin redness and inflammation. At just 0.1% concentration, it shows visible reduction in erythema within 15-60 minutes of application, making it ideal for sensitive skin formulations and products targeting redness reduction .

Formulation Versatility

Our CERAMIDE NP is compatible with various formulation systems including:

• Oil-based formulations (up to 0.5% concentration)
• Water-in-oil and oil-in-water emulsions (up to 2% concentration)
• Liposomal delivery systems for enhanced penetration
• Nanoparticle formulations for improved stability and efficacy

Excellent Stability

Rigorous stability testing over 12 months confirms that our CERAMIDE NP maintains consistent purity (±0.2%), appearance, melting point, and functional properties under recommended storage conditions 

Our CERAMIDE NP is suitable for a wide range of skincare applications:

Recommended Product Categories

• Barrier repair creams and moisturizers for dry/sensitive skin
• Anti-aging formulations including serums and eye creams
• Post-procedure skincare products for barrier restoration
• Sensitive skin treatments targeting redness reduction
• Premium cleansers that protect the skin barrier
• Body care products for conditions like eczema and xerosis
• Lip repair treatments for chapped and damaged lips

Formulation Recommendations

Table: Formulation Guidelines for Different Applications

Synergistic Combinations

For enhanced benefits, combine CERAMIDE NP with:

• Cholesterol and free fatty acids to replicate skin's natural lipid ratio
• Hyaluronic acid and glycerin for multi-level hydration
• Niacinamide for enhanced barrier function and redness reduction
• Antioxidants like vitamin E and C for comprehensive protection
• Peptides for synergistic anti-aging effects

We offer flexible ordering options to meet diverse customer needs:

• Sample Availability: Available in 25g, 50g, and 100g sizes for formulation development
• Minimum Order Quantity (MOQ): 1kg for standard material, 5kg for customized versions
• Standard Packaging: 1kg aluminum bags with PE liner, 5kg and 25kg containers
• Customization Options:

1. Purity levels (95%, 98%, 99%)
2. Particle size distribution
3. Customized documentation packages
4. Exclusive rights for large volume orders

• Lead Times: Samples within 3-5 business days, production quantities in 2-3 weeks

Our technical support team provides comprehensive assistance including:

• Formulation guidance and compatibility testing
• Regulatory support for different markets
• Stability testing protocols and assistance
• Claims support with clinical data references
• Custom development for specific application needs

Ready to enhance your formulations with premium CERAMIDE NP?

Contact our technical specialists today to discuss your specific requirements, request samples, or obtain detailed technical documentation.

Please include in your inquiry:

• Your company information and intended applications
• Required quantity and specifications
• Any specific customization needs
• Target markets and regulatory requirements

We respond to all inquiries within 24 business hours and are committed to building long-term partnerships through superior products and technical support.