Dipeptide‑2 – The Targeted Peptide for Under‑Eye Bags & Puffiness
Inhibits angiotensin‑converting enzyme (ACE), enhances lymphatic microcirculation, and promotes fluid drainage. Clinically proven to reduce under‑eye bags and oedema – for a more rested, youthful appearance.
Product Overview:
Dipeptide‑2 is a synthetic peptide specifically designed to combat periorbital oedema and eye bags. Under‑eye puffiness often results from weakened lymphatic circulation and increased capillary permeability, leading to fluid accumulation. Dipeptide‑2 works by inhibiting angiotensin‑converting enzyme (ACE) , which helps relax blood vessels, improve lymph flow, and facilitate the removal of excess fluid from the delicate eye area. The result is visibly reduced puffiness, smoother under‑eye contours, and a brighter, more alert look.
| Benefit | Mechanism / Data |
|---|---|
| 💧 Reduces under‑eye puffiness | Promotes lymphatic drainage and fluid expulsion – targets oedema directly. |
| 🧴 Inhibits ACE | 0.002% Dipeptide‑2 achieved 85% ACE inhibition (in vivo). |
| 📈 Increases water removal | 33% increase in fluid expulsion vs. placebo (6‑week clinical study). |
| 👁️ Visibly diminishes eye bags | Clinical photos show significant reduction in under‑eye bag size and severity. |
| 🌿 Safe & well‑tolerated | Non‑irritating, suitable for the sensitive eye area. |
| Parameter | Value |
|---|---|
| INCI Name | Dipeptide‑2 |
| Appearance | White to off‑white powder |
| Solubility | Water‑soluble |
| Recommended dosage | 0.001 – 0.01% (extremely potent; 0.002% clinically effective) |
| Formulation pH | 5.0 – 7.0 |
| Addition temperature | <50°C (cool‑down phase) |
| Applications | Eye creams, serums, gels, and anti‑puffiness patches. |
Proven Efficacy (6‑week clinical study, 0.002% Dipeptide‑2 cream, twice daily):
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ACE inhibition: 85%
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Fluid expulsion: 33% greater than placebo
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Visual assessment: marked reduction in under‑eye bags (photographic evidence)
Why Formulators Choose Dipeptide‑2:
✅ Clinically proven – low concentration (0.002%) delivers significant results.
✅ Targeted mechanism – specifically addresses lymphatic drainage and ACE.
✅ Ideal for eye area – gentle, non‑irritating.
✅ Synergistic – can be combined with caffeine, hyaluronic acid, or other de‑puffing actives.
Formulation Guidelines:
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Dosage: 0.001 – 0.01% (0.002% recommended for clinical efficacy).
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Addition: Add to water phase during cool‑down (<50°C).
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pH: 5.0‑7.0.
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Applications:
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Anti‑puffiness eye creams & serums
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Brightening eye gels
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Contour treatments for under‑eye bags
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Dipeptide‑2 – The smart solution for waking up to brighter, bag‑free eyes.
