Acetyl Tetrapeptide‑2 – The Thymopoietin‑Mimicking Peptide for Keratinocyte Renewal & Immune‑Boosting Skin Repair
Stimulates keratinocyte growth (+51% in 5 days), increases keratin production (+75%), upregulates collagen gene expression, and enhances skin immunity. Clinically proven to improve facial contours, reduce wrinkles, and restore elasticity in aged skin.
Product Overview:
Acetyl Tetrapeptide‑2 is a synthetic peptide designed to mimic the biological activity of thymopoietin, a natural hormone that regulates keratinocyte growth and differentiation. As we age, thymopoietin levels decline, leading to slower skin cell renewal, thinning epidermis, and accumulation of dull, corneocytes. Acetyl Tetrapeptide‑2 compensates for this loss by:
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Promoting keratinocyte proliferation – accelerates the formation of new, healthy skin cells.
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Increasing keratin production – strengthens the epidermal barrier and improves texture.
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Stimulating GM‑CSF (Granulocyte‑Macrophage Colony‑Stimulating Factor) – activates immune cells (macrophages, leukocytes) to defend against pathogens and UV damage.
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Upregulating collagen & elastin genes – enhances dermal matrix integrity, reducing wrinkles and improving firmness.
| Benefit | Mechanism / Data |
|---|---|
| 🧬 Accelerates keratinocyte growth | +51% increase in keratinocyte proliferation within 5 days (in vitro). |
| 🧴 Strengthens epidermal barrier | +75% increase in keratin production – improves skin resilience and texture. |
| 🛡️ Boosts skin immunity | Stimulates GM‑CSF production – enhances local immune defence (macrophages, leukocytes). |
| ✨ Upregulates collagen & elastin | Increases gene expression of collagen I, III, IV, and elastin – firms skin, reduces wrinkles. |
| 👩🦱 Clinical anti‑aging results | 6‑week study (n=20, age 55‑65, 2% cream, twice daily): improved facial contours, reduced fine lines, increased elasticity. |
| Parameter | Value |
|---|---|
| INCI Name | Acetyl Tetrapeptide‑2 |
| Appearance | White to off‑white powder |
| Solubility | Water‑soluble |
| Recommended dosage | 1 – 5% (typically 2‑3% in anti‑aging creams/serums) |
| Formulation pH | 4.0 – 7.0 |
| Addition temperature | <50°C (cool‑down phase) |
| Applications | Anti‑aging creams, firming serums, neck and décolleté treatments, immune‑supporting skincare. |
Proven Efficacy (summary):
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In vitro:
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Keratinocyte proliferation: +51% in 5 days.
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Keratin production: +75%.
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GM‑CSF secretion significantly increased.
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Collagen I, III, IV, and elastin gene expression upregulated.
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In vivo (6 weeks, n=20, age 55‑65, 2% cream twice daily):
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Improved facial contours (lifting effect).
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Visible reduction in fine lines and wrinkles.
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Increased skin elasticity.
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Why Formulators Choose Acetyl Tetrapeptide‑2:
✅ Dual action – boosts epidermal renewal and dermal collagen synthesis.
✅ Immune‑enhancing – unique GM‑CSF stimulation for skin defence.
✅ Clinically proven – visible results in 6 weeks.
✅ Safe & well‑tolerated – non‑irritating, suitable for sensitive skin.
✅ Premium brand recognition – used by Lancôme, Dior, Chanel.
Formulation Guidelines:
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Dosage: 1 – 5% (2‑3% optimal for anti‑aging formulas).
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Addition: Add to water phase during cool‑down (<50°C).
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pH: 4.0‑7.0.
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Applications:
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Anti‑wrinkle night creams
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Firming serums for face and neck
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Skin barrier repair moisturisers
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Post‑procedure immune‑supporting formulas
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Acetyl Tetrapeptide‑2 – The peptide that rebuilds skin from within: faster renewal, stronger defence, younger contours.
