Hexapeptide‑11 – The Cellular Youth Preserver that Activates Proteostasis & Fights Oxidative Ageing
A yeast‑derived peptide that enhances the cell’s own protein quality control systems – proteasome, autophagy, and chaperones. Protects fibroblasts from oxidative stress, improves skin elasticity, and visibly reduces wrinkles. Used by global luxury brands.
Product Overview:
Hexapeptide‑11 is a synthetic peptide originally isolated from yeast extract. It acts as a unique anti‑ageing agent by targeting proteostasis – the cellular machinery that maintains protein health. With age, damaged and misfolded proteins accumulate, impairing cell function. Hexapeptide‑11 activates three key systems: the proteasome (degrades damaged proteins), autophagy (recycles cellular components), and molecular chaperones (assists correct protein folding). By boosting these processes, it helps fibroblasts resist oxidative stress, delays premature senescence, and promotes a more youthful, resilient extracellular matrix.
| Benefit | Mechanism / Data |
|---|---|
| 🧬 Enhances cellular proteostasis | Activates proteasome, autophagy, and chaperone systems – restores protein quality control, reduces accumulation of damaged proteins. |
| 🛡️ Protects against oxidative stress | In vitro: H₂O₂‑induced oxidative damage significantly reduced in fibroblasts treated with Hexapeptide‑11 (SA‑β‑GAL staining). |
| ✨ Improves skin elasticity | 4‑week clinical study (2.8% Hexapeptide‑11, twice daily, eye and cheek area): initial elastic response (Ue) significantly improved – skin feels firmer and more resilient. |
| 📉 Reduces wrinkles | Visible reduction in fine lines and improved skin firmness after 4 weeks (photographic evidence). |
| 🌿 Safe & well‑tolerated | Non‑irritating, suitable for sensitive skin. |
| Parameter | Value |
|---|---|
| INCI Name | Hexapeptide‑11 |
| Appearance | White to off‑white powder |
| Solubility | Water‑soluble |
| Recommended dosage | 1 – 5% (typical 2‑3% in anti‑ageing serums/creams) |
| Formulation pH | 5.0 – 7.0 |
| Addition temperature | <50°C (cool‑down phase) |
| Applications | Anti‑ageing serums, firming creams, eye contour treatments, elasticity‑repair formulas. |
Proven Efficacy (summary):
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In vitro (human fibroblasts): Hexapeptide‑11 significantly reduced H₂O₂‑induced oxidative damage and premature senescence (SA‑β‑GAL staining).
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In vivo (4 weeks, n=25, 2.8% Hexapeptide‑11 cream, twice daily):
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Visible reduction in wrinkles and improved skin firmness (photo documentation).
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Initial elastic response (Ue) significantly improved – indicating better skin resilience. Total deformation (Uf) unchanged, highlighting the peptide’s specific tightening effect.
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Why Formulators Choose Hexapeptide‑11:
✅ Unique mechanism – targets proteostasis, not just collagen stimulation.
✅ Protects against oxidative ageing – helps fibroblasts resist damage.
✅ Clinically proven – 4‑week study shows improved elasticity and wrinkle reduction.
✅ Premium brand recognition – used by Estée Lauder, Chanel, and other luxury houses.
✅ Safe & gentle – non‑irritating, ideal for anti‑ageing serums and eye creams.
Formulation Guidelines:
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Dosage: 1 – 5% (2‑3% for optimal anti‑ageing).
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Addition: Add to water phase during cool‑down (<50°C).
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pH: 5.0‑7.0.
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Applications:
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Anti‑wrinkle serums & creams
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Skin firming & lifting products
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Eye contour treatments
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Elasticity repair formulas
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Hexapeptide‑11 – The peptide that keeps your skin cells clean, protected, and young.
