HYDROXYPINACOLONE RETINOATE (HPR) widely used in anti-aging acne lotions, creams, essence, masks

Product Characteristics

Hydroxy pinacolone retinoate (HPR), CAS No. 893412-73-2, or HPR for short, belongs to the family of Retinoids, which has the function of regulating the metabolism of the epidermis and the stratum corneum, and can be used as an anti-aging agent, which can reduce seborrhoeic overflows, lighten epidermal pigmentation, and play a role in preventing skin aging, preventing acne, whitening and lightening spots.

Hydroxy pinacolone retinoate is a retinol derivative modified with hydroxy pinacolone. Unlike other retinoic acid (retinoic acid) derivatives, it does not need to be converted to exert its activity directly, and its effect is more direct, with smaller molecular weight, easier to be absorbed transdermally, and it exhibits low irritation and high stability, which is an obvious advantage compared with various other types of retinol-like products.

Among the various retinol derivatives, hydroxypinacolone retinoate ensures the powerful effect of retinol while greatly reducing its irritation. Hydroxy pinacolone retinoate was more potent than other retinoid derivatives at the transcriptional level of anti-degenerative genes at the same concentration, and showed lower cytotoxicity at 10-fold higher concentrations.HPR significantly promoted the synthesis of procollagen relative to untreated controls, and histological examination showed that the highest dose of HPR was more potent than trans retinoic acid, but induced less inflammation (as marked by IL-1α). . Thus, hydroxy pinacolone retinoate is an alternative to retinoic acid for skin anti-aging but with fewer skin side effects.

As a new generation of VA-based anti-aging products, hydroxypinacolone retinoid offers the benefits of retinol and retinol-like derivatives with minimal skin irritation, providing consumers with translucent, visually visible and rejuvenated skin. The mechanism of action of hydroxypinacolone retinoate is more advantageous than that of retinol derivatives: in order to bind to retinoid receptors, retinol must first be enzymatically metabolized to other active forms, such as retinaldehyde and vitamin A acid (retinoic acid). However, hydroxypinacolone retinoate, with its unique inherent retinoic acid properties, binds directly to retinoid receptors without metabolizing into other biologically active forms, resulting in a significant improvement in the appearance of facial skin, and no optical toxicity has been detected with daily use, so daytime use is not a problem.

Product Effect.

HPR directly activates the corresponding receptor without conversion

HPR has the advantages of both retinol and A ester, and has the innate ability to bind to retinoic acid receptors, directly interacting with the receptors, without the need for metabolic changes and biodegradation into other forms of transformation, reducing irritation while maximizing the retention of activity.

10 times more stable than ordinary retinol

Good stability is a prerequisite for product efficacy, and recent studies have shown that HPR is the most stable of a range of vitamin A derivatives, based on the results of long-term and accelerated stability tests. After the claimed shelf life, its measured content is still an astonishing 95.2%.

Improvement of skin laxity by HPR

As we age, our skin becomes thinner and less elastic, which can lead to sagging and fine lines. HPR stimulates the proliferation of skin cells, restoring the skin's original thickness and preventing the formation of wrinkles, and its effect on the filling of fine lines and wrinkles is shown in the chart on the right: (After using a cream containing 0.2% HPR, the skin's fine lines were significantly reduced compared with the placebo group, while the skin's translucency was improved and the skin's color became healthy and even. became healthy and even.)