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NIKOO Chemical - Skincare Raw Material Supply and Custom Solution Specialist for 15 years. 

NK‑C6001 STEPHANIA TETRANDRA EXTRACT – Fast‑Acting Soothing Complex for Itch, Redness & Allergic Skin

A synergistic botanical blend of oat avenanthramides and Stephania tetrandra (tetrandrine) – calms itching in 3‑5 minutes, inhibits histamine release, and reduces neurodermatitis symptoms.
NK‑C6001 STEPHANIA TETRANDRA EXTRACT – Fast‑Acting Soothing Complex for Itch, Redness & Allergic Skin 1

Product Overview:
NK‑C6001 is a scientifically designed anti‑irritant complex that targets the root causes of skin sensitivity, itching, and inflammation. It combines two powerful plant‑derived actives:

  • Oat (Avena sativa) kernel extract – standardized for avenanthramides. These phenolic compounds have been used for centuries in colloidal oatmeal to soothe itchy, irritated skin. Clinical studies on 250 subjects show that avenanthramides at as low as 0.025% quickly reduce erythema in UV‑ and chemical‑induced redness models.

  • Stephania tetrandra extract – contains tetrandrine, a natural bisbenzylisoquinoline alkaloid. Tetrandrine acts as both an allergy‑mediator antagonist and a mediator release blocker. It suppresses inflammation at multiple steps, reduces oxygen free radicals from macrophages, and mimics some effects of corticosteroids without the side effects.

The formula also includes isopentyldioldipotassium glycyrrhizate, and bis‑ethoxydiglycol cyclohexane 1,4‑dicarboxylate (a soothing synergist) to enhance fast penetration and long‑lasting comfort.

Key Benefits at a Glance:
Benefit Mechanism Speed
⚡ Rapid itching relief Avenanthramides + tetrandrine block pruritus signals; skin feels calm within 3‑5 minutes Immediate
🛡️ Anti‑histamine & anti‑allergic Inhibits histamine release from mast cells; competes with histamine at receptors Fast onset
🌿 Anti‑inflammatory Tetrandrine suppresses multiple inflammatory pathways (macrophage oxygen consumption, free radicals) – effective for allergic & neurodermatitis Cumulative
❤️ Reduces erythema 0.025% avenanthramides proven to reduce UV‑ and chemical‑induced redness Within 1‑2 applications
🧴 Soothes neurodermatitis & eczema Calms chronic itchy, thickened skin; helps break the scratch‑itch cycle Visible in a few days
💧 Lightweight & water‑soluble Easy to formulate into serums, essences, lotions, and creams -
Technical Specifications:
Parameter Value
Product code NK‑C6001
INCI (partial) Water, Isopentyldiol, Butylene Glycol, Dihydroavenanthramide D, Stephania Tetrandra Extract, Bis‑Ethoxydiglycol Cyclohexane 1,4‑Dicarboxylate, 1,2‑Hexanediol, Dipotassium Glycyrrhizate
Appearance Colorless to pale yellow viscous clear liquid
Odor Slightly characteristic
pH (3% solution) 3.5 – 4.5 (batch tested: 4.26)
Solubility Easily soluble in water
Recommended dosage 0.5 – 2.0%
Microbial limits Total bacterial count <10 CFU/ml; mould & yeast <10 CFU/ml
Packaging 10 kg / drum
Storage Dry, cool, sealed

Clinical & Descriptive Efficacy:

  • Anti‑itch: On‑skin application relieves itch sensation in 3‑5 minutes.

  • Anti‑histamine: Proven to control histamine release – useful for allergic contact dermatitis, urticaria, and insect bites.

  • Anti‑inflammatory: Effective for both acute and chronic inflammatory skin conditions (neurodermatitis, eczema, psoriasis adjunct).

  • Redness reduction: Avenanthramides at only 0.025% quickly reduce UV‑induced erythema (clinical, n=250).

Why Formulators Choose NK‑C6001:
✅ Dual botanical action – avenanthramides + tetrandrine, two complementary anti‑irritant mechanisms.
✅ Fast visible results – consumers feel relief within minutes.
✅ Water‑soluble & easy to use – add at <50°C, no special solvents.
✅ Low use level – 0.5‑2% is effective, cost‑efficient.
✅ Mild & non‑irritating – no steroids, no synthetic antihistamines.

Formulation Guidelines:

  • Dosage: 0.5 – 2.0% (1‑2% for intensive anti‑itch serums; 0.5‑1% for daily soothing products).

  • Addition: Add during cool‑down phase (<50°C) to the water phase.

  • pH compatibility: Works at pH 4‑7; slightly acidic formula is optimal.

  • Applications:

    • Anti‑itch calming serums

    • After‑sun / insect bite gels

    • Sensitive skin toners & essences

    • Eczema / neurodermatitis creams

    • Post‑shave balms

    • Scalp soothing tonics

NK‑C6001 – When skin screams “itch!”, answer with fast, botanical calm.

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