NK‑C6013 α‑Arbutin – Next‑Generation Whitening Agent | High Purity, Safe, and Synergistic
ULA‑C6013 α‑Arbutin is a high‑performance, biotechnologically produced whitening agent. It is manufactured using the latest enzymatic fermentation technology, achieving a purity of ≥99.0% and excellent solubility. α‑Arbutin rapidly penetrates the skin and, without affecting cell proliferation, effectively inhibits tyrosinase activity – the key enzyme in melanin synthesis. It blocks melanin formation, accelerates the decomposition and excretion of existing melanin, and reduces hyperpigmentation, freckles, and age spots. Unlike many other whitening agents, α‑Arbutin is non‑toxic, non‑irritating, and non‑sensitising to melanocytes. It also possesses mild antibacterial and anti‑inflammatory properties.
| Benefit | Description |
|---|---|
| 🧪 High purity | ≥99.0% α‑Arbutin, low by‑products |
| ⚡ High efficacy at low dosage | Only 1/5 to 1/4 of β‑Arbutin required |
| 🔒 No hydroquinone release | Safe – does not degrade to hydroquinone |
| 🌟 No cytotoxicity | Does not inhibit cell growth; melanocyte‑friendly |
| 🧴 Excellent stability | Resists discolouration and degradation |
| 🤝 Synergistic | Works with niacinamide, AA2G, tranexamic acid derivatives |
| Feature | α‑Arbutin | β‑Arbutin |
|---|---|---|
| Relative dosage | 1× | 4‑5× more |
| Tyrosinase inhibition | Stronger (monophenolase) | Weaker |
| Hydroquinone release risk | None | Possible |
| Colour stability | Excellent | May discolour |
| Cytotoxicity | None | Low risk |
| Parameter | Value |
|---|---|
| INCI Name | Alpha‑Arbutin |
| Molecular formula | C₁₂H₁₆O₇ |
| Molecular weight | 272.25 |
| CAS No. | 84380‑01‑8 |
| Appearance | White to off‑white crystalline powder |
| Odor | Slight characteristic |
| Purity (HPLC) | ≥99.0% |
| Melting point | 203.0 – 206.0°C |
| Specific rotation | +174.0° – +186.0° |
| pH (3% solution) | 5.0 – 7.0 |
| Hydroquinone limit | ≤5 ppm |
| Heavy metals | ≤10 ppm |
| Arsenic | ≤2 ppm |
| Microbial limits | Total <1000 cfu/g; yeast/mould <100 cfu/g; no pathogens |
Formulation Guidelines:
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Solubility: 151 g/L in water at 20°C (easily soluble in hot water and ethanol, slightly soluble in cold water).
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pH stability: Optimal at pH 4.0 – 6.5.
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Temperature: Add at <70°C (cool‑down phase) to maintain activity.
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Recommended dosage:
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Toners / watery serums: 0.2 – 2.0%
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Essences / ampoules: 0.2 – 2.0%
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Emulsions, creams, gels: 0.3 – 3.0%
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Sheet masks: 0.3 – 2.0%
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BB / CC creams: 0.5 – 2.0%
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Synergistic combinations:
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With niacinamide (0.5 – 1.0%) – enhanced brightening.
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For whitening‑claim products (e.g., special licence creams): α‑Arbutin 1.0‑2.0% + niacinamide 0.5‑1.0% + AA2G (Ascorbyl Glucoside) 1‑2%.
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Applications:
Whitening serums, brightening toners, anti‑spot creams, freckle‑removing formulations, BB/CC creams, after‑sun brightening products, and high‑end facial masks.
Packaging & Storage:
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Packaging: 25 kg/drum or 1 kg/aluminium foil bag.
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Storage: Keep tightly closed in a cool, dry place away from light.
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Shelf life: 2 years under recommended conditions.
