PDRN – The Regenerative DNA Complex for Tissue Repair, Anti‑Aging & Skin Rejuvenation
Polydeoxyribonucleotide from salmon sperm DNA – 98% homologous to human DNA. Activates adenosine A2A receptors, accelerates wound healing, reduces scars, tightens pores, and restores youthful skin.
Product Overview:
PDRN (Polydeoxyribonucleotide) is a high‑purity DNA derivative extracted from salmon sperm cells. Salmon DNA shares up to 98% sequence homology with human DNA, ensuring excellent biocompatibility and minimal risk of immune reactions. PDRN is obtained through controlled purification and sterilisation, removing any potentially immunogenic proteins or peptides.
Mechanism of Action:
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Adenosine A2A receptor activation – PDRN binds specifically to A2A receptors on cell surfaces, triggering a cascade of tissue‑repair signals.
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Salvage pathway – provides nucleotides and nucleosides that fuel DNA synthesis and cell proliferation.
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Growth factor release – stimulates the production of VEGF, angiopoietin, and transglutaminase II, improving blood circulation and cell regeneration.
| Benefit | Mechanism / Evidence |
|---|---|
| 🩹 Wound healing & tissue regeneration | Promotes fibroblast proliferation, collagen synthesis, and re‑epithelialisation. Effective in post‑surgical, post‑laser, and burn care. |
| 🧴 Scar & acne mark reduction | Clinical study (0.5% PDRN, 16 weeks) significantly improved scar colour, softness, and thickness vs. placebo. Also reduces Acne scars, acne marks |
| ✨ Anti‑aging & collagen boost | In vitro: PDRN significantly increased collagen production in human dermal fibroblasts (24‑72h). In vivo: 0.5% PDRN for 4 weeks improved skin elasticity and reduced fine lines. |
| 💧 Pore tightening | 0.5% PDRN for 4 weeks visibly reduced pore size (20 female volunteers, age 18‑36). |
| 🌿 Anti‑inflammatory | Activates A2A receptors to reduce inflammation; clinical case: CRPS (complex regional pain syndrome) skin flushing resolved in 1 day. |
| ☀️ UV protection & whitening | Reduces UV‑induced damage; clinical observations show PDRN injections lighten hyperpigmentation after 3 sessions (4 weeks). |
| 🧪 High safety | No immunogenicity (no proteins/peptides), heat‑stable (121°C for 30 min), pH 6‑8 stable. |
| Parameter | Value |
|---|---|
| Product name | Polydeoxyribonucleotide (PDRN) |
| Source | Salmon sperm (fish reproductive cells) |
| Purity (powder form) | High (≥60% DNA content from raw material) |
| Appearance (powder) | White fibrous or powder |
| Appearance (solution) | Clear, colourless to pale yellow (5000 ppm stock) |
| Solubility | Water‑soluble |
| Heat stability | 121°C for 30 minutes – stable |
| pH stability | 6 – 8 (optimal 7‑8 for storage) |
| Recommended dosage (powder) | 0.03 – 0.5% |
| Recommended dosage (5000 ppm stock) | 6 – 100% (can be used as base) |
| Storage | 2 – 8°C, protect from light |
| Shelf life | 2 years |
| Applications | Regenerative creams, serums, masks, post‑procedure gels, scar treatment patches, anti‑aging formulations, hair tonics |
Clinical & Study Highlights:
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Collagen synthesis (in vitro): PDRN significantly increased collagen production in fibroblasts (p<0.05).
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Scar improvement (16 weeks, n=100): PDRN group showed marked improvement in POSAS scores (colour, pliability, thickness) vs. placebo.
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Pore tightening (4 weeks, n=20): 0.5% PDRN reduced pore size visibly.
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Whitening (clinical observation): 3 injection sessions (once monthly) lightened pigmentation.
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CRPS skin flushing: resolved within 1 day after PDRN injection.
Why Formulators Choose PDRN:
✅ Multi‑functional – healing, anti‑aging, scar reduction, pore tightening, whitening.
✅ Biomimetic – high DNA homology, no immune rejection.
✅ Stable & easy to use – heat‑tolerant, water‑soluble, wide pH range.
✅ Backed by clinical evidence – from wound healing to aesthetic dermatology.
✅ Versatile – leave‑on, rinse‑off, injectable (medical grade).
Formulation Guidelines:
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Dosage (powder): 0.03‑0.5% (0.1‑0.5% for anti‑aging/scar repair; 0.03‑0.1% for maintenance).
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Dosage (5000 ppm stock solution): 1‑10% for serums/creams; up to 100% as a mask base.
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Addition: Dissolve in water phase at room temperature or <50°C.
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pH: Optimal 5‑9, stable at 6‑8.
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Applications:
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Post‑laser / post‑surgery repair gels
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Anti‑aging & firming serums
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Scar & acne mark patches / creams
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Pore‑tightening toners / masks
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Whitening ampoules (synergistic with vitamin C, arbutin)
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PDRN – The DNA of skin regeneration. From wound healing to age reversal.
