Recombinant Humanised Filaggrin: Unlocking the ‘Biological Shield’ for Skin Barrier Repair

As a revolutionary ingredient in skin barrier repair, recombinant humanised filaggrin precisely replicates the structure of human natural filaggrin through genetic engineering technology. It functions through a dual mechanism of ‘biomimetic reconstruction + intelligent moisturisation,’ making it a core ingredient for the care of dry and sensitive skin. Its unique amino acid sequence directly supplements filaggrin deficiencies caused by genetic defects or environmental damage, thereby strengthening the skin's protective barrier from the root cause.

Core Mechanism and Technical Advantages

1. Barrier Reconstruction Engine: Filaggrin degradation produces natural moisturising factors (NMF) accounting for 30% of the total, which can increase ceramide synthesis in the stratum corneum by 42% and reduce transepidermal water loss (TEWL) by 58%. Clinical tests show that after four weeks of using a cream containing 2% recombinant human-derived filaggrin, skin barrier function recovery rate reaches 89%;

2. Long-lasting Moisturising Network: Rich in amino acids such as histidine and arginine, it can bind 150 times its own weight in water, forming a dynamic moisture-locking film, with a 65% increase in 8-hour sustained moisturising efficiency;

3. Anti-Sensitivity and Anti-Inflammatory Synergy: Inhibits the release of inflammatory factors such as IL-6 and TNF-α (reduced by 71%), and when used with ceramides, reduces redness in sensitive skin by 63%.

Diverse application scenarios

- Sensitive skin repair cream: Recommended addition rate of 1%-3%, quickly relieves dryness, itching, and stinging, with a 79% reduction in sensitive skin recurrence rate after 28 days;

- Baby care products: Uses a mild formula (0.8% concentration), passed human patch testing (0% sensitisation rate), effectively prevents nappy rash;

- Post-Aesthetic Surgery Care: Added to masks (2% concentration) to accelerate epidermal layer repair after laser surgery, reducing healing time by 35%;

- Autumn/Winter Moisturising Series: Blended with hyaluronic acid to enhance skin hydration and elasticity, with a 91% improvement rate in dryness and flakiness.