SYN‑AKE – The Smart Peptide for Natural Expression Line Relaxation
A synthetic tripeptide inspired by snake venom – blocks nicotinic acetylcholine receptors, relaxes facial muscles, and visibly reduces crow’s feet and forehead wrinkles. Clinically proven results without injections or loss of natural expression.
Product Overview:
SYN‑AKE (INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a biomimetic peptide developed based on the venom of the temple viper (Tropidolaemus wagleri). Unlike botulinum toxin (Botox), which cleaves SNARE proteins and can cause permanent muscle paralysis with potential side effects, SYN‑AKE acts as a reversible, competitive antagonist of the nicotinic acetylcholine receptor at the post‑synaptic membrane. It binds to the ε‑subunit of the receptor, preventing acetylcholine from triggering muscle contraction. This relaxes the underlying facial muscles, smoothing dynamic wrinkles while preserving natural facial expression.
| Benefit | Mechanism / Data |
|---|---|
| 🧬 Relaxes expression lines | Competitively blocks nicotinic acetylcholine receptors (ε‑subunit) → reduces muscle contraction frequency. |
| ⚡ Fast & long‑lasting action | In vitro: within 2 hours, muscle contraction decreased by 82%; effect lasted up to 4 days (reversible). |
| ✨ Visible wrinkle reduction | 28‑day clinical study (4% SYN‑AKE cream): significant decrease in roughness parameters (Ra, Rz, Rt); optical imaging showed reduced crow’s feet depth and total wrinkle volume. |
| 🌿 Safe & non‑irritating | No injection, no risk of unnatural freezing of expression; reversible action, no long‑term muscle atrophy. |
| 🧴 Synergistic with other actives | Can be combined with collagen‑boosting ingredients (e.g., GHK‑Cu) for comprehensive anti‑aging. |
| Parameter | Value |
|---|---|
| INCI Name | Dipeptide Diaminobutyroyl Benzylamide Diacetate |
| Appearance | White to off‑white powder |
| Solubility | Water‑soluble |
| Recommended dosage | 1 – 10% (typically 2‑5% in serums/creams) |
| Formulation pH | 4.0 – 7.0 |
| Addition temperature | <50°C (cool‑down phase) |
| Applications | Anti‑wrinkle serums, eye creams, facial masks, daily moisturisers for expression lines. |
Proven Efficacy (summary):
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In vitro (muscle cell contraction assay):
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0.05 mM SYN‑AKE reduced muscle contraction frequency by 82% after 2 hours.
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Effect remained 67% lower after 2 days, returned to baseline after 4 days – demonstrating reversible, safe action.
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In vivo (28‑day clinical study, n=30, 4% SYN‑AKE cream):
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Significant reduction in skin roughness parameters (Ra, Rz, Rt).
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Optical imaging (fast optical imaging method) showed visible reduction in crow’s feet depth and total wrinkle area.
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Why Formulators Choose SYN‑AKE:
✅ Mimics Botox without injection – relaxes expression lines without freezing face.
✅ Reversible and safe – no permanent muscle damage.
✅ Clinically proven – in vitro and 28‑day human results.
✅ Easy to formulate – water‑soluble, stable at pH 4‑7.
✅ Consumer‑friendly – natural expression preserved, no “mask‑like” appearance.
Formulation Guidelines:
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Dosage: 1 – 10% (2‑5% for daily anti‑wrinkle; up to 10% for intensive treatment).
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Addition: Add to water phase at <50°C.
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pH: 4.0 – 7.0 (optimal 5‑6).
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Applications:
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Crow’s feet serums & eye creams
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Forehead & frown line relaxing creams
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Anti‑aging masks
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Daily moisturisers for expression‑prone skin
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SYN‑AKE – The reversible, peptide‑based alternative to Botox for natural, youthful expression lines.
