Acetyl Tetrapeptide-15 – Premium Skincare Raw Material from China

Next-Generation Neuropeptide for Advanced Skincare Formulations

Our Acetyl Dipeptide-1 Cetyl Ester (INCI: Acetyl Dipeptide-1 Cetyl Ester, CAS: 196604-48-5), also known as Acetyl Dipeptide-1 Hexadecyl Ester, is a high-purity, bioactive neuropeptide that represents cutting-edge innovation in sensitive skin care and anti-aging technology. it offers dual biological activity by simultaneously addressing skin sensitivity concerns and providing anti-aging benefits without causing irritation. This makes it significantly more effective and gentler than conventional approaches . Our Acetyl Dipeptide-1 Cetyl Ester is specially engineered for formulators seeking to create high-performance skincare products that deliver visible soothing and anti-aging results within 28 days without causing sensitivity or irritation, even for consumers with highly reactive skin .

With its unique molecular structure that features an acetyl group attached to a dipeptide sequence esterified with cetyl alcohol, our Acetyl Dipeptide-1 Cetyl Ester provides superior efficacy, enhanced skin penetration, and prolonged activity in cosmetic formulations, making it the ideal choice for brands targeting consumers who seek clinical-grade calming and rejuvenation results without invasive procedures

Our Acetyl Dipeptide-1 Cetyl Ester is manufactured through a proprietary synthesis technology that combines traditional peptide chemistry with advanced esterification techniques 

• Unprotected Amino Acid Synthesis: We utilize a innovative approach using side chain-unprotected arginine and tyrosine amino acids, significantly reducing production costs compared to traditional methods requiring protected amino acids .
• Intermediate Preparation: The process begins with synthesizing arginine cetyl ester p-toluenesulfonate salt by reacting arginine with cetyl alcohol in the presence of p-toluenesulfonic acid in toluene solvent, with azeotropic water removal .
• Peptide Coupling: The intermediate is then coupled with acetyl tyrosine using coupling reagents such as HBTU and DIEA in solvents like DMF, acetonitrile, or THF at controlled temperatures of 25-30°C .
• Crystallization Purification: The crude product undergoes a specialized crystallization process involving dissolution in methanol followed by gradual addition of ethyl acetate to induce crystallization, resulting in high-purity final product .
• Green Chemistry Principles: Our patented process eliminates multiple protection and deprotection steps required in conventional peptide synthesis, reducing solvent waste, energy consumption, and production time .
• Comprehensive Quality Control: Each batch undergoes rigorous analytical testing including HPLC for purity assessment, mass spectrometry for identity confirmation, amino acid analysis for composition verification, and stability testing under various conditions to ensure compliance with stringent quality standards 

As a leading manufacturer of advanced skincare active ingredients, we offer distinct advantages that make us the preferred partner for skincare brands worldwide:

• Significant Production Capacity: With large-scale production facilities and fully automated synthesis systems, we can reliably supply both small development quantities (from 1g) and large commercial volumes (kg scale) with consistent quality .
• Cost-Effective Production: Our proprietary synthesis method reduces production costs by approximately 40% compared to conventional methods, allowing us to offer competitive pricing without compromising quality .
• Customization Flexibility: We offer Acetyl Dipeptide-1 Cetyl Ester in various purity grades (95%, 98%, 99%) and can provide custom formulations tailored to specific application needs 
• Global Logistics Expertise: Established export expertise with efficient shipping solutions to major international markets, supported by comprehensive documentation including certificates of analysis, safety data sheets, and customs documentation 

Our Acetyl Dipeptide-1 Cetyl Ester offers exceptional performance characteristics that make it ideal for advanced skincare formulations:

Superior Soothing and Anti-Irritation Effects

Acetyl Dipeptide-1 Cetyl Ester demonstrates significant soothing capabilities by stimulating skin nerve cells to release met-enkephalin, an opioid messenger molecule that provides relaxing and pain-relieving effects. This instantly decreases skin irritations from heat, chemical stinging, or mechanical stresses

Dual Mechanism of Action

The peptide works through multiple mechanisms to provide comprehensive skin benefits:

• Neuropeptide Activity: Acts as a "messenger of tranquility and muscle relaxation" by modulating neurotransmitter activity in the skin 
• Vascular Regulation: Inhibits CGRP and substance P mediators, controlling plasma extravasation and microvascular dilation phenomena, thereby reducing redness and inflammation 
• Barrier Enhancement: Increases expression of genes encoding skin barrier function proteins including AQP3, FLG, caspase-14, and cytokeratin 10 in primary human keratinocytes

Multi-Action Benefits

Beyond its primary soothing effects, Acetyl Dipeptide-1 Cetyl Ester provides comprehensive skincare benefits:

• Reduces appearance of fine lines and wrinkles by relaxing facial muscles and preventing dynamic expression lines 
• Enhances skin repair processes by accelerating cellular regeneration and barrier recovery 
• Improves skin resilience by reducing neural responsiveness to irritants and increasing tolerance thresholds 
• Provides antioxidant protection by reducing glyoxal-induced formation of advanced glycation end products (AGEs) in human fibroblasts 
• Stimulates elastic protein synthesis to combat skin laxity and improve firmness 

Enhanced Safety Profile

Unlike some active ingredients, our Acetyl Dipeptide-1 Cetyl Ester offers:

• Non-irritating application through topical formulations with a safety risk factor of 1 
• Excellent tolerance even for sensitive skin types and no comedogenicity 
• No recovery time or associated procedure risks
• Suitable for long-term use without safety concerns
• Pregnancy-safe formulation compatibility

Formulation Versatility

Our Acetyl Dipeptide-1 Cetyl Ester is compatible with various formulation systems including:

• Water-based serums and solutions
• Oil-in-water and water-in-oil emulsions
• Advanced delivery systems for enhanced penetration
• Various cosmetic formulations including creams, lotions, and serums 

Excellent Stability

Rigorous stability testing confirms that our Acetyl Dipeptide-1 Cetyl Ester maintains consistent purity and performance when stored under recommended conditions (2-8°C, protected from light) and formulated in appropriate systems 

Our Acetyl Dipeptide-1 Cetyl Ester is suitable for a wide range of skincare applications:

Recommended Product Categories

• Sensitive skin treatments for face and body 
• Anti-redness creams and serums for reducing visible redness and inflammation 
• Anti-aging products for preventing and reducing expression lines 
• Post-procedure treatments for calming and soothing after cosmetic procedures
• Barrier repair formulations for enhancing skin resilience 
• Targeted treatments for specific sensitive areas

Formulation Recommendations

Table: Formulation Guidelines for Different Applications

Synergistic Combinations

For enhanced benefits, combine Acetyl Dipeptide-1 Cetyl Ester with:

• Hyaluronic acid for hydration and barrier enhancement 
• Niacinamide for additional barrier improvement and redness reduction
• Antioxidants (Vitamin C, E) for comprehensive protection against environmental stressors 
• Other peptides for multi-mechanism anti-aging action
• Growth factors for enhanced skin rejuvenation and repair

Stability Considerations

To maximize stability and performance in formulations:

• Maintain pH between 5.0-7.0 for optimal stability
• Avoid prolonged heating above 40°C during manufacturing
• Use appropriate preservatives in aqueous systems
• Consider encapsulation for enhanced stability in challenging systems
• Package in airless containers with UV protection to preserve efficacy

We offer flexible ordering options to meet diverse customer needs:

• Sample Availability: Available in 1g, 10g, and 100g sizes for formulation development

• Minimum Order Quantity (MOQ): 1g for standard material

• Standard Packaging: 1g glass vials with rubber stoppers for optimal preservation

• Customization Options:

1. Different purity grades  (95%, 98%, 99%)
   
2. Customized documentation packages
3. Exclusive rights for large volume orders
4. Private labeling and OEM services

• Lead Times: Samples within 3-5 business days, production quantities in 2-3 weeks

Our technical support team provides comprehensive assistance including:

• Formulation guidance and compatibility testing
• Regulatory support for different markets (EU, USA, ASEAN, etc.)
• Stability testing protocols and assistance
• Claims support with clinical data references
• Custom development for specific application needs

Ready to enhance your formulations with premium Acetyl Dipeptide-1 Cetyl Ester?

Contact our technical specialists today to discuss your specific requirements, request samples, or obtain detailed technical documentation.

Please include in your inquiry:

• Your company information and intended applications
• Required quantity and specifications
• Any specific customization needs
• Target markets and regulatory requirements

We respond to all inquiries within 24 business hours and are committed to building long-term partnerships through superior products and technical support.