Application of Nano Liposomal Vitamin C in Skin Care

Overview of Liposome Technology

Liposome encapsulation technology allows for the nano-scale application of vitamin C. This technology involves encapsulating vitamin C within liposomes, forming nanoscale drug carriers. This nanoscale vitamin C not only has higher bioavailability but also effectively enhances the therapeutic effect of the drug.

Technology Introduction
Liposome encapsulation technology encapsulates vitamin C within liposomes, forming nanoscale drug carriers, thereby improving bioavailability and therapeutic effect.

Nanoscale Application
Liposomes nanoscale vitamin C, making it easier for the skin to absorb and enhancing the drug's efficacy.

Detailed Explanation of Liposome Technology

Liposomes, hailed as "artificial biological membranes," are based on the core technology of mimicking the structure of biological membranes to encapsulate drug molecules or bioactive components, forming nanoscale drug carriers. This technology not only significantly improves drug bioavailability but also helps enhance the therapeutic effect of the drug.

Basic Characteristics

1. Concept and Explanation: Liposomes are tiny vesicles formed by encapsulating drug molecules within a lipid bilayer. The phospholipid bilayer, a biological membrane in the human body, is the inspiration for liposomes. Liposomes mimic the structure of biological membranes, exhibiting excellent biocompatibility and thus enabling efficient drug delivery.

2. Amphiphilicity and Stability: Liposomes possess unique amphiphilicity, their structure resembling a combination of a match head and a matchstick. This property allows liposomes to flexibly carry and release different types of drug molecules. For example, vitamin C, a water-soluble vitamin, can be contained by the hydrophilic end of the liposome; while collagen, a non-water-soluble fibrous glycoprotein, can be carried by the lipophilic end.

Thermosensitive Liposomes: Upon reaching the phase transition temperature, their lipid bilayer membrane undergoes a transition from a colloidal to a liquid crystal state, leading to increased lipid membrane permeability and accelerating drug release. These liposomes, acting as non-viral carriers, can fuse with cell membranes to deliver desired substances into cells. After delivery, the liposomes are degraded, ensuring safety, non-toxicity, and no immunogenicity. Thermosensitive liposomes change structure at the phase transition temperature to release drugs safely and non-toxicly.

Vitamin C and Skin

Vitamin C's Functions in the Skin

Fortunately, Vitamin C effectively inhibits tyrosinase activity, blocks melanin production, and protects the skin from UV damage. It can also reduce existing melanin to colorless melanin precursors, thus improving dull skin. Vitamin C inhibits tyrosinase activity, reduces melanin formation, and has antioxidant properties.

Nanoactive Vitamin C is a novel type of Vitamin C nanoliposome formulation. Vitamin C inhibits tyrosinase activity, effectively inhibits melanin synthesis, promotes collagen synthesis, improves dull skin, and gives the skin elasticity; it has strong antioxidant properties, effectively scavenging free radicals; and the nano-encapsulation effectively improves the stability and bioavailability of Vitamin C. Chinese Name: Nano Liposomal Vitamin C; Nano-encapsulated Vitamin C; Water-soluble Vitamin C; Bioactive Vitamin C; Nano Vitamin C; Oil-soluble Vitamin C; Fat-soluble Vitamin C; Amphiphilic Vitamin C

Product Name: Nano Liposomal Vitamin C; Nanoactive Vitamin C; BioaActive Vitamin C; BioActive VC; NanoActive VC; Oil Soluble Vitamin C; Fat Oil Soluble Vitamin C; Water Soluble Vitamin C;

CAS: 50-81-7

Description: Vitamin C (Ascorbic Acid), also known as L-ascorbic acid, is a water-soluble vitamin. Vitamin C is an important antioxidant that participates in various reactions in the body, promoting collagen production, blocking melanin synthesis, scavenging free radicals, and preventing skin aging. It is one of the most classic and effective active ingredients in cosmetics. Vitamin C is insoluble in fat-soluble systems and is extremely unstable in aqueous solutions, which greatly limits its use. Although various vitamin C derivatives have been developed and used, they must be converted into the original vitamin C in the body to be effective, which greatly reduces their activity. L-ascorbic acid (“L-C”) is the only form of vitamin C that can be directly absorbed by human skin. NanoActive C is a L-ascorbic acid nanoparticle with an average particle size of less than 30 nanometers, developed using a nanotransport system (NDS). It solves the problems of vitamin C solubility and stability, allowing vitamin C to be stably encapsulated within a nanocarrier, significantly increasing absorption rate and bioavailability, and greatly expanding its application range.

Vitamin C Physiological Activities

• Antiscurvy Activity (Promotes Collagen Synthesis)
• Antioxidant Properties
• Inhibits Melanin Synthesis
• Enhances the Immune System

Product Features

• NanoActive C is a non-chemically modified, stable, L-ascorbic acid nanoparticle that can exert its effects directly and efficiently without in vivo conversion.
• NanoActive C uses GRAS (Generally Recognized As Safe) grade raw materials, ensuring high safety and non-irritation.
• NanoActive C is 100% water-soluble and 100% oil-soluble (amphiphilic), broadening its applicability.
• NanoActive C significantly improves the stability and bioavailability of vitamin C.
• NanoActive C exhibits good thermal, pH, and shear stability, making it easy to use.

Product Efficacy

• NanoActive C inhibits melanin formation and reduces melanin by suppressing tyrosinase activity, fading existing spots, eliminating pigmentation, and reducing sunspots and freckles caused by sun exposure.
• It protects the skin from UV damage, such as acquired wrinkles.
• L-ascorbic acid (vitamin C) is essential for collagen production, a major component of the dermis. NanoActive C promotes collagen synthesis and reduces fine lines.
• NanoActive C effectively neutralizes free radicals, promotes skin metabolism, accelerates skin renewal, improves skin texture, restores damaged skin, and makes skin firm and elastic.
• NanoActive C enhances the stability of other active ingredients in the product and promotes their absorption.

Potential Uses of NanoActive:

Maintaining skin elasticity

– Enhancing collagen synthesis

Whitening effect

– Antioxidant properties (reducing effect)

– Inhibits tyrosinase activity

Preventing skin inflammation and photoaging

– Antioxidant properties (eliminating hydroxyl free radicals)

Product Usage: Add at room temperature. Heating to above 40°C can accelerate dissolution. Recommended dosage: 1-5%. Better results when used in conjunction with products containing vitamin E and ferulic acid.

Product Storage: Store below 25°C, protected from light.