NIKOO Chemical - Skincare Raw Material Supply and Custom Solution Specialist for 15 years.

Decoding the "Communication Language" of the Skin Microbiome | Bifida Ferment Lysate

2026-01-26

NK-051 Bifida Ferment Lysate: Controlling the problem at its source and improving skin's natural environment.

Applying thick layers of expensive anti-aging creams every night, yet seeing no results? Using high-end face masks daily, only to find your skin becoming drier and itchier? Applying all sorts of serums, yet your skin is still red and breaking out? Frequent sensitivity despite meticulous skincare may indicate an imbalance in your skin's microbiome!

The skin's microbiome is a dynamic, balanced system composed of bacteria, fungi, viruses, and other microorganisms, weighing approximately 200 grams in total, with millions of microorganisms residing per square centimeter; these invisible life forms construct a defense network more intelligent than physical barriers. When improper cleansing or over-care disrupts this balance, it leads to dysbiosis, resulting in a cascade of skin problems!

Microbiome Skincare: The Next Golden Age of Scientific Skincare

Definition of Microbiome Skincare: Microbiome skincare refers to using active ingredients to promote the growth of "good bacteria" and reduce the number of "bad bacteria" on the skin, fundamentally maintaining the balance of the skin's microbiome, allowing the skin to possess powerful defense and repair capabilities. With the popularization of scientific skincare concepts and the breaking of the dilemma of treating symptoms but not the root cause, the demand for microecological skincare products will continue to grow, and the market size is expected to reach 10.54 billion yuan in 2025, with a compound annual growth rate of 26%. This will also become the focus of many brands vying to develop their products.

NK-051 Microbiome Skincare's Star Ingredient

01 Patented Technology, Superior Quality

*Patent Name: A Method for Preparing Bifidobacterium Longum Fermentation Product Filtrate and its Lysate

*Patent Application Number: CN202410984482.2BEN-051 The Bifida Fermentation Product Lysate utilizes a patented technology, inducing and selecting Bifidobacterium Longum CGMCCNo.31133 strain from over 2000 microorganisms. Through specific fermentation, centrifugation, and special lysis steps, the active ingredients are fully released, maximizing their utilization value.

Strain Advantages
Maximized Product Utilization
Rich Ingredients
Significant Efficacy
High Active Content

02 Superior to competitors, high activity content. NK-051 Bifida Ferment Lysate boasts solid strength! It is rich in small molecule organic acids such as lactic acid and acetic acid, with contents that are 16.9 times and 2.8 times higher than those of imported competitors, respectively; the solid content is the same as that of imported competitors.

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Soothing and Anti-inflammatory

Based on a 3D epidermal skin model (EpiKutis®), compared with the control group, the BEN-051 Bifida ferment lysate showed inhibition rates of 36.18%, 27.80%, and 61.77% against inflammatory factors (IL-1α), inflammatory mediators (PGE2), and nuclear transcription factor (NF-κB), respectively.

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Maintaining a stable skin microbiome

β-defensin 1 (HBD-1), β-defensin 2 (HBD-2), and antimicrobial peptide LL-37 (LL-37) are important components of the skin microbiome; BEN-051 Bifida ferment lysate increased the levels of β-defensin 1 (HBD-1), β-defensin 2 (HBD-2), and antimicrobial peptide LL-37 (LL-37) by 195.83%, 215.38%, and 231.82%, respectively.

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Whitening and Brightening
Based on a 3D epidermal skin model (EpiKutis®), compared with the control group, the apparent color of the BEN-051 Bifida ferment lysate was significantly whiter, with an apparent brightness (L* value) increase of 14.54% and a melanin inhibition rate of 16.36%.

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Advantages Summary

Superior Strains: The strains used grow rapidly, have high bacterial density, and are rich in high-content metabolites.
Patented Process: Produced using a patented process, resulting in abundant and high-content active ingredients with significant efficacy.
High Activity Content: Lactic acid content ≈ 16.9 times that of imported competitors; acetic acid content ≈ 2.8 times that of imported competitors.
Significant Efficacy: Exhibits excellent performance in anti-inflammatory and soothing effects, skin whitening and brightening, and stabilizing the microecological environment, with an increase in microecological immune factors of approximately 200%.

If you are interested in this product or have any questions, please feel free to contact our professional sales team. You can email us at rebecca@nikoochem.com, and our sales representatives will be happy to provide you with detailed product information and professional consultation services.

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