Injection grade/topical grade MELITTIN for anti-wrinkle, oil control acne, acne products

Product Characteristics

Bee venom peptide (Melitten) is the main component and the main bioactive substance of bee venom, accounting for about 40%-50% of the dry weight of bee venom, and it is a peptide composed of 26 amino acid residues. Natural bee venom is easily soluble in water, but its clinical application has many limitations, mainly due to the difficulty of removing phospholipase A2, which is allergenic and close to the molecular weight of bee venom peptide, from bee venom by existing technology. Therefore, our company utilizes the solid phase synthesis method to prepare high purity bee venom peptide without sensitizing activity, which can perfectly avoid the risk of sensitization.

Melitten plays a major pharmacological role in bee venom and is one of the strongest anti-inflammatory substances known to man. It has hormone-like effects without the adverse effects of hormones. 100 times more anti-inflammatory than hydrocortisone, Melitten can inhibit the growth and reproduction of more than 20 kinds of Gram-negative and positive bacteria, especially Melitten can be resistant to penicillin-resistant Staphylococcus aureus, Melitten can also enhance the antibacterial efficacy of sulfonamides and penicillins, and has inhibitory effect on a variety of fungi, viruses, and so on. Melitten has a significant analgesic effect, its inhibitory effect on prostaglandin synthase is 70 times that of morphine, and its analgesic strength is 40% that of morphine, and the duration of analgesia is longer. melitten also inhibits the transfer of leukocytes, which inhibits local inflammatory reactions. In addition, Melitten also has antibacterial, antiradical and antiviral effects; Melitten can pierce the protective outer layer of HIV and destroy HIV without harming the surrounding normal cells.

Melitten inhibits inflammatory signaling pathways, and by inhibiting these pathways, Melitten reduces the activation of inflammatory factors. This inhibition reduces inflammation in tissues such as skin, nasal passages, joints, liver and neurons. In addition, Bee Venom Peptide can act on the nervous system, and its selective blocking effect on acetylcholine receptors blocks the excitatory conduction of the central nervous system and exerts anti-wrinkle effects.

• Melitten molecules assemble on the surface of bacterial membranes
• Melitten molecules form ring-shaped perforations on the membrane surface
• Bacterial membranes disintegrate and bacteria die as concentration increases