NK‑021 Bifida Ferment Filtrate – Multi‑Functional Postbiotic for Whitening, Anti‑Oxidant & Anti‑Acne
A 99% pure, preservative‑stabilised filtrate of Bifidobacterium longum metabolites – delivering clinically proven whitening, soothing, and antimicrobial efficacy.
Product Overview:
Bifidobacterium longum (also known as Bifida yeast) is a Gram‑positive, anaerobic bacterium naturally present in the human gut. It was first isolated in 1899 from healthy breastfed infants. Its metabolites – including lactic acid, acetic acid, amino acids, oligopeptides, and B vitamins (B1, B2, B3, B6, B9, B12, biotin) – have remarkable skin benefits.
NK‑021 is a sterile, cell‑free filtrate obtained after controlled fermentation, inactivation, and decomposition of B. longum. It contains the full spectrum of postbiotic actives, without live bacteria. The product is supplied as a ready‑to‑use liquid with a mild preservative system (0.5% hydroxyacetophenone + 0.5% 1,2‑hexanediol) for formulation stability.
| Benefit | Mechanism | Test Data |
|---|---|---|
| ✨ Whitening & brightening | Inhibits tyrosinase activity – blocks melanin synthesis | 90.30% tyrosinase inhibition (100 mg/mL) |
| ⚡ Anti‑oxidant | Scavenges free radicals, prevents oxidative stress | 18.87% free radical scavenging (100 mg/mL) |
| 🌿 Anti‑inflammatory & soothing | Reduces NO production – calms irritation, redness | 6.36% NO reduction (P<0.05) |
| 🦠 Anti‑acne | Clear zone of inhibition against Cutibacterium acnes | >7 mm inhibition zone – effective |
| 💧 Hydration & barrier support | Lactic/acetic acids improve pH, strengthen stratum corneum | - |
| 🛡️ Photoaging protection | Anti‑immunosuppressive activity – protects against UV damage | - |
| Parameter | Value |
|---|---|
| Product code | NK‑021 |
| INCI Name | Bifida Ferment Filtrate (and) Hydroxyacetophenone (and) 1,2‑Hexanediol |
| Composition | 99% Bifida ferment filtrate + 0.5% hydroxyacetophenone + 0.5% 1,2‑hexanediol |
| Appearance | Clear to slightly opalescent liquid |
| Odor | Characteristic (mild, fermented) |
| Solubility | Water‑soluble |
| Recommended dosage | 1.0 – 89.55% (can be used as a base) |
| pH (as supplied) | 5.0 – 6.5 |
| Applications | Toners, essences, sheet masks, serums, gels, acne treatments |
Proven Efficacy (in‑vitro):
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Tyrosinase inhibition assay: 90.30% inhibition at 100 mg/mL – statistically significant (P<0.05) vs. blank control.
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DPPH radical scavenging: 18.87% at 100 mg/mL – significant anti‑wrinkle potential (P<0.05).
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NO (nitric oxide) suppression: 6.36% reduction in LPS‑induced RAW264.7 macrophages – significant soothing effect (P<0.05).
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Antibacterial test (against C. acnes): Clear inhibition zone >7 mm – confirms anti‑acne efficacy.
Why NK‑021 Stands Out:
✅ High purity – 99% ferment filtrate, minimal preservatives.
✅ Multi‑functional – whitening, antioxidant, anti‑inflammatory, anti‑acne, hydrating.
✅ Clinically‑inspired – based on decades of probiotic research.
✅ Easy to formulate – water‑compatible, stable, ready to use.
✅ Gentle – no live bacteria, no irritation.
Formulation Guidelines:
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Dosage: Use at 1‑90%. Can serve as the main water phase in masks and toners.
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Addition: Add at any stage (heat‑stable). For high‑temperature processing, keep below 80°C to preserve delicate metabolites.
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Compatibility: Compatible with most non‑ionic, anionic, and amphoteric ingredients.
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Applications:
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Whitening & brightening serums
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Soothing toners & essences
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Anti‑acne gels & spot treatments
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Sheet mask bases (up to 89.55%)
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After‑sun repair formulations
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NK‑021 – The postbiotic powerhouse that brightens, calms, and clears – all in one liquid.
