Pro.MT Recombinant Metallothionein – The Master Antioxidant for Photoprotection & Skin Brightening
Product Overview:
Metallothionein (MT) is an endogenous, low‑molecular‑weight protein (approx. 6‑7 kDa) naturally present in mammalian cells. It contains ≈30% cysteine residues with characteristic Cys‑x‑Cys or Cys‑x‑y‑Cys sequences, arranged into α and β domains that form a dumbbell‑shaped dimer. The abundant thiol (‑SH) groups bind divalent metal ions, regulating metal homeostasis and scavenging free radicals.
Pro.MT is a recombinant metallothionein produced via biotech fermentation and supplied as a high‑purity lyophilised powder. It acts as the “master conductor” of the body’s antioxidant defence system:
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Direct radical scavenging – quenches hydroxyl radicals (·OH), superoxide anions (O₂⁻), and other ROS, preventing lipid peroxidation, DNA damage, and melanin synthesis.
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Activates other antioxidants – upregulates SOD, GSH (glutathione), and NADP⁺/NADPH cycling, creating a sustained antioxidant network.
| Benefit | Mechanism / Data |
|---|---|
| ☀️ Anti‑photoaging | Scavenges up to 90% of UV‑induced free radicals – prevents collagen/elastin degradation |
| ✨ Whitening & anti‑pigmentation | Binds copper at the tyrosinase active site – inhibits melanin synthesis |
| ⚡ Extreme antioxidant power | 50‑100× stronger than GSH; 340× faster reaction rate with ·OH; 10,000× faster than SOD |
| 🧬 Cellular defence | Protects against lipid peroxidation & DNA oxidative damage; prevents apoptosis |
| 🔄 Activates antioxidant network | Enhances SOD activity, boosts GSH expression, supports NADPH recycling |
| 🌿 Safe & biocompatible | Endogenous human protein – no toxicity, no irritation |
| Parameter | Value |
|---|---|
| INCI Name | CYSTEINE,Trehalose |
| Source | Recombinant (E. coli / yeast expression system) |
| Molecular weight | 6 – 7 kDa |
| Cysteine content | ≈30% |
| Appearance | White to off‑white lyophilised powder (freeze‑dried) |
| Solubility | Soluble in water and dilute buffers |
| Purity | ≥95% (by SDS‑PAGE) |
| Heavy metal binding | High affinity for Zn²⁺, Cu²⁺, Cd²⁺ (used in detoxification) |
| Recommended dosage | 0.01 – 0.1% (due to extremely high potency) |
| Formulation | Add to water phase at <40°C (cool‑down), pH 5.0‑7.0 |
| Applications | Anti‑aging serums, after‑sun repair, whitening ampoules, antioxidant boosters, sensitive skin care |
| Comparison | MT | GSH | SOD |
|---|---|---|---|
| Relative antioxidant power | 50‑100× | 1× | – |
| Reaction rate with ·OH | 340× faster | 1× | – |
| Radical scavenging spectrum | Broad | Moderate | Narrow (O₂⁻ only) |
| Activates other antioxidants | Yes (master regulator) | No | No |
Formulation Guidelines:
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Dosage: Start at 0.01‑0.05% for most products; up to 0.1% for intensive repair.
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Addition: Add to the water phase after cooling to <40°C. Avoid high heat and strong oxidising agents.
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pH stability: 5.0‑7.0.
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Storage: Lyophilised powder is stable at room temperature; reconstituted solutions should be used immediately or stored at 4°C with preservative.
Applications:
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Anti‑aging & photoprotection serums – prevents UV‑induced free radical damage.
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After‑sun / post‑laser repair – calms oxidative stress, accelerates healing.
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Whitening & spot‑correcting products – inhibits tyrosinase, reduces pigmentation.
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Antioxidant boosters – revitalises mature or damaged skin.
Pro.MT – The master antioxidant that protects, whitens, and activates your skin’s own defence network.
