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NIKOO Chemical - Skincare Raw Material Supply and Custom Solution Specialist for 15 years. 

NK‑022 Lactobacillus Ferment Filtrate – Postbiotic Power for Microbiome Balance, Brightening & Barrier Protection

A 99% pure, ready‑to‑use filtrate from probiotic Lactobacillus fermentation – rich in peptides, polysaccharides, and B vitamins. Clinically proven to whiten, soothe, fight acne, and strengthen the skin microbiome.
NK‑022 Lactobacillus Ferment Filtrate – Postbiotic Power for Microbiome Balance, Brightening & Barrier Protection 1

Product Overview:
Lactobacillus ferment filtrate is obtained by cultivating Lactobacillus species, then inactivating and filtering the culture to retain all the beneficial metabolites produced during fermentation – including peptidoglycan, teichoic acid, phospholipids, sterols, fatty acids, enzymes, peptides, amino acids, nucleotides, and extracellular polysaccharides. It contains no live bacteria, only the postbiotic actives.

NK‑022 is a high‑purity (99%) liquid formulated with a mild preservative system (0.5% hydroxyacetophenone + 0.5% 1,2‑hexanediol) for stability. It can be used as a main base (up to 90%) or as an active ingredient in various formulations.

Key Benefits at a Glance:
Benefit Mechanism Test Data
✨ Whitening & brightening Inhibits tyrosinase activity – reduces melanin synthesis 88.01% tyrosinase inhibition (100 mg/mL)
⚡ Antioxidant Scavenges free radicals – prevents oxidative stress 13.05% DPPH radical scavenging (100 mg/mL)
🌿 Soothing & anti‑inflammatory Reduces NO production – calms irritation, redness 3.08% NO reduction (P<0.05)
🦠 Anti‑acne Natural antibacterial peptides – inhibits C. acnes >7 mm inhibition zone – effective
💧 Deep hydration Rich in lactic acid & sodium lactate (NMF components) Boosts stratum corneum moisture, reduces TEWL
🛡️ Microbiome support Forms a protective biofilm – balances skin flora, prevents pathogen adhesion -
🔄 Barrier repair Strengthens stratum corneum metabolism, removes dead skin, improves pigmentation -
Technical Specifications:
Parameter Value
Product code NK‑022
INCI Name Lactobacillus Ferment, 1,2‑Hexanediol, Hydroxyacetophenone
Composition 99% Lactobacillus ferment filtrate + 0.5% 1,2‑hexanediol + 0.5% hydroxyacetophenone
Appearance Colorless to pale yellow clear transparent liquid
Odor Characteristic (mild, slightly lactic)
pH 4.0 – 7.0
Solubility Fully water‑soluble
Heat resistance Stable at 40±1°C for 24h
Cold resistance Stable at -8±2°C for 24h
Recommended dosage 1.0 – 90.0% (can be used as main base in masks/toners)
Applications Face masks, serums, toners, waterless formulas, acne treatments, soothing essences
Packaging 25 kg / 200 kg drum
Shelf life 24 months (sealed, room temperature, dry place)

Proven Efficacy (in‑vitro):

  • Tyrosinase inhibition: 88.01% at 100 mg/mL – superior whitening efficacy (P<0.05 vs. blank).

  • DPPH radical scavenging: 13.05% at 100 mg/mL – significant antioxidant/anti‑wrinkle potential (P<0.05).

  • NO (nitric oxide) suppression: 3.08% reduction in LPS‑induced RAW264.7 macrophages – significant soothing effect (P<0.05).

  • Antibacterial (against C. acnes): Inhibition zone diameter >7 mm – confirms anti‑acne activity.

Why NK‑022 Stands Out:
✅ Ultra‑high purity – 99% ferment filtrate, minimal preservatives.
✅ Multi‑functional – whitening, antioxidant, anti‑inflammatory, anti‑acne, moisturising, microbiome balancing.
✅ Natural & gentle – no live bacteria, no harsh chemicals, mimics skin’s natural NMF.
✅ Extremely versatile – can be used from 1% to 90%, even as the main water phase.
✅ Scientifically supported – data on tyrosinase, DPPH, NO, and antibacterial activity.

Formulation Guidelines:

  • Dosage: 1‑90% depending on desired efficacy. For sheet masks and toners, up to 90% can be used as the base.

  • Addition: Add at any stage (heat‑stable up to 80°C). For optimal preservation, add during cool‑down phase.

  • Compatibility: Compatible with most non‑ionic, anionic, and amphoteric ingredients.

  • Applications:

    • Whitening & brightening serums

    • Soothing & anti‑redness toners

    • Anti‑acne gels & spot treatments

    • Sheet mask bases (up to 90%)

    • Waterless / anhydrous formulations

    • Microbiome‑friendly daily moisturisers

NK‑022 – The complete postbiotic ferment that brightens, calms, clears, and protects – from the inside of your formula to the surface of your skin.

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