NIKOO Chemical - Skincare Raw Material Supply and Custom Solution Specialist for 15 years.

NK‑C6014 VC‑IP (Ascorbyl Tetraisopalmitate) – The Ultra‑Stable, Oil‑Soluble Vitamin C for Superior Whitening & Anti‑Aging

2026-05-18

A highly stable, lipophilic vitamin C derivative – approved by global health authorities. Penetrates deep, converts to active VC, and delivers powerful brightening, antioxidant, and collagen‑boosting benefits without irritation.

NK‑C6014 VC‑IP (Ascorbyl Tetraisopalmitate) – The Ultra‑Stable, Oil‑Soluble Vitamin C for Superior Whitening & Anti‑Aging 1

Product Overview:
Ascorbyl Tetraisopalmitate (VC‑IP) is the most stable vitamin C derivative available. By esterifying the hydroxyl groups of ascorbic acid with isopalmitic acid, it becomes oil‑soluble, heat‑stable, and resistant to oxidation from light and air. Once absorbed, skin enzymes hydrolyse it back to free vitamin C, providing all the benefits of L‑ascorbic acid – but without the formulation headaches.

Regulatory Approvals:

Japan (MHLW): Quasi‑drug ingredient, recommended 3%
Korea (MFDS): Functional whitening ingredient, recommended 2%
Taiwan (TFDA): One of 13 permitted whitening actives for “medicated cosmetics”, recommended 3%
Australia (AICS): Registered at 1%
Widely used in global brands for over a decade

**Key Benefits at a Glance:**
Benefit	Mechanism
✨ Whitening & spot fading	Inhibits tyrosinase, reduces melanin synthesis, and reduces already‑formed melanin (converts DOPAquinone back to DOPA)
🧴 Excellent stability	No discolouration under light, heat, or air; can be used in hot process and transparent packaging
💧 High skin penetration	Oil‑soluble, easily penetrates stratum corneum; absorption rate 3× higher than water‑soluble ascorbic acid in epidermal cells
🛡️ Antioxidant powerhouse	Scavenges free radicals, protects against UV‑induced oxidative stress, prevents lipid peroxidation
🧬 Collagen booster	Stimulates collagen synthesis, reduces collagen degradation → smooths wrinkles, firms skin
🌿 Anti‑inflammatory & anti‑acne	Reduces inflammation, helps treat acne, prevents sebum oxidation and blackhead formation
☀️ Photo‑protection	Protects skin from UV damage (pigmentation, dryness, photoaging); used in sunscreens

**Technical Specifications:**
Parameter	Value
Product code	NK‑C6014
INCI Name	Ascorbyl Tetraisopalmitate
CAS No.	183476‑82‑6
Molecular formula	C₇₀H₁₂₈O₁₀
Molecular weight	1129.8
Appearance	Colourless to pale yellow oily liquid
Odor	Slight characteristic
Purity	≥98% (HPLC)
Density	0.930 – 0.945 g/ml
Refractive index (25°C)	1.459 – 1.465
Colour (APHA)	≤100
Solubility	Soluble in oils, esters, ethanol, glycerin, glycols; insoluble in water
Heavy metals	≤10 mg/kg
Arsenic	≤2 mg/kg
Microbial limits	<10 CFU/g bacteria & yeast/mould
Recommended dosage	1.0 – 5.0% (up to 10‑20% for speciality products)
Applications	Creams, lotions, serums, sunscreens, anti‑aging formulas, whitening products

**Why Formulators Choose VC‑IP Over Other Vitamin C Derivatives:**
Feature	L‑Ascorbic Acid	3‑O‑Ethyl Ascorbic Acid	Ascorbyl Glucoside	VC‑IP (Ascorbyl Tetraisopalmitate)
Oil solubility	No	No	No	Yes
Thermal stability	Poor	Good	Moderate	Excellent
Light/air stability	Poor	Good	Moderate	Excellent
Penetration enhancement	Low (pH dependent)	Good	Moderate	Very high
Conversion to active VC	Low (pH dependent)	Enzymatic	Enzymatic	Enzymatic (high efficiency)
Irritation potential	High at low pH	Low	Low	Very low
Regulatory approvals (global)	General	General	General	Quasi‑drug status in JP/KR/TW

Formulation Guidelines:

Dosage: 1 – 5% (2‑3% for general whitening; 5% for intensive anti‑aging).
Addition: Add to the oil phase before emulsification, or directly into anhydrous systems. Heat‑stable – can be added during hot process.
pH compatibility: No strict pH restriction; works across 4‑8 range.
Applications:
- Whitening & brightening creams / lotions
- Anti‑aging serums (collagen boosting)
- Sunscreens (antioxidant booster)
- Acne treatment formulas (anti‑inflammatory, sebum control)
- Anhydrous serums & balms