Brand Name: NIKOOCHEM
Place of Origin: Guangdong, China
Product Names: Palmitoyl hexapeptide-12
Chemical Name: Palmitoyl hexapeptide-12
INCI: Palmitoyl hexapeptide-12
CAS: 171263-26-6
Molecular formula: C₃₈H₆₈N₆O₈
Molecular weight: 736.98 g/mol
Appearance:White to off-white powder or transparent liquid
Purity: ≥98 %(HPLC)
Sequence:Pal-Val-Gly-Val-Ala-Pro-Gly
Solubility: Water-soluble
Storage:2-8°C, protected from light, desiccated
Shelf Life:24 months in original packaging
Recommended Usage: 2-10 ppm in leave-on products
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active
Next-Generation Signal Peptide for Advanced Skincare Formulations
Product Overview
Our Palmitoyl Hexapeptide-12 (INCI: Palmitoyl Hexapeptide-12, CAS: 171263-26-6), also known as Lipopeptide or Pal-VGVAPG, is a high-purity and a synthetic signal peptide ingredient primarily used in skincare products. It stimulates collagen production and improves skin elasticity, resulting in anti-wrinkle and firming benefits. Compared to traditional peptides, it offers improved stability and transdermal absorption, is more suitable for sensitive skin, and is a common active ingredient in anti-aging formulations.
Palmitoyl hexapeptide-12 belongs to the "signal peptide" category. By simulating the skin's own repair signals, it activates fibroblast function and promotes the synthesis of type I collagen, elastin, and hyaluronic acid. This mechanism can directly improve fine lines and sagging caused by collagen loss, while strengthening the skin barrier and reducing the accelerated effects of external stimuli on aging.
Advanced Production Process
Our Palmitoyl Hexapeptide-12 is manufactured through a proprietary microchannel modular synthesis technology that combines traditional peptide chemistry with advanced continuous flow techniques
Factory Advantages & Manufacturing Capabilities
As a leading manufacturer of advanced skincare active ingredients, we offer distinct advantages that make us the preferred partner for skincare brands worldwide:
Product Characteristics & Performance Benefits
Our Palmitoyl Hexapeptide-12 offers exceptional performance characteristics that make it ideal for advanced skincare formulations:
Superior Elastin Stimulation
Palmitoyl Hexapeptide-12 demonstrates significant elastin production capabilities by promoting the synthesis of elastin and other extracellular matrix components in the dermal layer. Clinical studies show visible improvement in skin elasticity and firmness with regular use
Mechanism of Action
The peptide works as a matrikine signal peptide that specifically targets age-related skin damage repair. It exhibits chemotactic properties that promote dermal fibroblast migration, proliferation, and synthesis of macromolecules such as elastin and collagen, providing structural support to the skin
Multi-Action Benefits
Beyond elastin stimulation, Palmitoyl Hexapeptide-12 provides comprehensive skincare benefits:
Anti-Inflammatory Properties
Research demonstrates that Palmitoyl Hexapeptide-12 can reduce interleukin-6 (IL-6) production in key skin cells, including keratin-forming cells and fibroblasts. Since IL-6 promotes inflammation and accelerates skin matrix degradation, this reduction helps slow down skin matrix breakdown, resulting in fewer wrinkles and improved skin tightness and elasticity
Enhanced Safety Profile
Unlike some active ingredients, our Palmitoyl Hexapeptide-12 offers:
Formulation Versatility
Our Palmitoyl Hexapeptide-12 is compatible with various formulation systems including:
Excellent Stability
Rigorous stability testing confirms that our Palmitoyl Hexapeptide-12 maintains consistent purity and performance when stored under recommended conditions (2-8°C, protected from light) and formulated in appropriate systems
Applications & Formulation Guidance
Our Palmitoyl Hexapeptide-12 is suitable for a wide range of skincare applications:
Recommended Product Categories
Formulation Recommendations
Table: Formulation Guidelines for Different Applications
Product Type | Recommended Usage | Key Benefits | Formulation Tips |
Face Serums | 5-10 ppm | Intensive wrinkle reduction | Incorporate in water phase; add at low temperature (<40°C) |
Moisturizers | 2-5 ppm | Daily prevention, mild correction | Add during cooling phase; ensure pH compatibility |
Eye Products | 4-8 ppm | Crow's feet reduction, expression line softening | Combine with soothing agents; ensure gentle formulation |
Preventive Products | 2-5 ppm | Early aging prevention, muscle relaxation | Suitable for lighter textures; target younger demographics |
Targeted Treatments | 7-10 ppm | Focused wrinkle correction | Higher concentrations for specific area treatment |
Synergistic Combinations
For enhanced benefits, combine Palmitoyl Hexapeptide-12 with:
Stability Considerations
To maximize stability and performance in formulations:
Ordering Information & Customer Support
We offer flexible ordering options to meet diverse customer needs:
Our technical support team provides comprehensive assistance including:
Contact Us for Samples & Technical Information
Ready to enhance your formulations with premium Palmitoyl Hexapeptide-12?
Contact our technical specialists today to discuss your specific requirements, request samples, or obtain detailed technical documentation.
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