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NIKOO Chemical - Skincare Raw Material Supply and Custom Solution Specialist for 15 years. 

Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 1
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 2
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 3
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 4
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 5
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 6
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 7
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 1
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 2
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 3
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 4
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 5
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 6
Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active 7

Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active

Brand Name:  NIKOOCHEM

Place of Origin:  Guangdong, China

Product Names:  Palmitoyl hexapeptide-12

Chemical Name: Palmitoyl hexapeptide-12

INCI: Palmitoyl hexapeptide-12

CAS: 171263-26-6

Molecular formula: C₃₈H₆₈N₆O₈
Molecular weight: 736.98 g/mol

Appearance:White to off-white powder or transparent liquid 

Purity: ≥98 %(HPLC)

Sequence:Pal-Val-Gly-Val-Ala-Pro-Gly

Solubility: Water-soluble

Storage:2-8°C, protected from light, desiccated

Shelf Life:24 months in original packaging

Recommended Usage: 2-10 ppm in leave-on products

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    Palmitoyl Hexapeptide-12 (Lipopeptide) - Premium Anti-Aging Peptide Active

    Next-Generation Signal Peptide for Advanced Skincare Formulations


    Product Overview

    Our Palmitoyl Hexapeptide-12 (INCI: Palmitoyl Hexapeptide-12, CAS: 171263-26-6), also known as Lipopeptide or Pal-VGVAPG, is a high-purity and a synthetic signal peptide ingredient primarily used in skincare products. It stimulates collagen production and improves skin elasticity, resulting in anti-wrinkle and firming benefits. Compared to traditional peptides, it offers improved stability and transdermal absorption, is more suitable for sensitive skin, and is a common active ingredient in anti-aging formulations.


    Palmitoyl hexapeptide-12 belongs to the "signal peptide" category. By simulating the skin's own repair signals, it activates fibroblast function and promotes the synthesis of type I collagen, elastin, and hyaluronic acid. This mechanism can directly improve fine lines and sagging caused by collagen loss, while strengthening the skin barrier and reducing the accelerated effects of external stimuli on aging.






    Advanced Production Process

    Our Palmitoyl Hexapeptide-12 is manufactured through a proprietary microchannel modular synthesis technology that combines traditional peptide chemistry with advanced continuous flow techniques 



    • Microchannel Reaction Technology: We utilize a patented microchannel modular reaction device that enables precise control of reaction parameters. The process begins with activated Boc-Pro-OH and H-Gly-OPg being pumped into the first micro-structure reactor via metering pumps for initial coupling
    • Stepwise Peptide Assembly: The reaction mixture undergoes washing and extraction in a second micro-structure reactor to remove impurities, followed by Boc deprotection using TFA in a third micro-structure reactor. This process is repeated sequentially to add remaining amino acids and the palmitoyl group according to the desired peptide sequence
    • Green Chemistry Principles: Our innovative microchannel technology significantly reduces consumption of amino acid raw materials, coupling reagents, and organic solvents while minimizing waste generation. The process offers high yields, excellent reproducibility, and is suitable for large-scale production .
    • Purification and Isolation: The fully protected peptide undergoes final deprotection of the C-terminal protecting group, followed by purification using preparative liquid chromatography to obtain the final product with high purity .
    • Quality Enhancement: The purified peptide undergoes a stabilization process that enhances shelf stability and ensures consistent performance in final formulations. This includes careful control of particle size distribution and moisture content .
    • Comprehensive Quality Control: Each batch undergoes rigorous analytical testing including HPLC for purity assessment, mass spectrometry for identity confirmation, amino acid analysis for composition verification, and stability testing under various conditions to ensure compliance with stringent quality standards




    Factory Advantages & Manufacturing Capabilities

    As a leading manufacturer of advanced skincare active ingredients, we offer distinct advantages that make us the preferred partner for skincare brands worldwide:


    • Proprietary Synthesis Technology: Our advanced microchannel reactor platform enables production of Palmitoyl Hexapeptide-12 with exceptional purity (≥99%) and batch-to-batch consistency, overcoming traditional peptide synthesis challenges 
    • Significant Production Capacity: With large-scale production facilities and fully automated synthesis systems, we can reliably supply both small development quantities (from 1g) and large commercial volumes (kg scale) with consistent quality .
    • Customization Flexibility: We offer Palmitoyl Hexapeptide-12 in various purity grades (95%, 98%, 99%) and can provide custom formulations tailored to specific application needs .




    Product Characteristics & Performance Benefits

    Our Palmitoyl Hexapeptide-12 offers exceptional performance characteristics that make it ideal for advanced skincare formulations:



    Superior Elastin Stimulation

    Palmitoyl Hexapeptide-12 demonstrates significant elastin production capabilities by promoting the synthesis of elastin and other extracellular matrix components in the dermal layer. Clinical studies show visible improvement in skin elasticity and firmness with regular use




    Mechanism of Action


    The peptide works as a matrikine signal peptide that specifically targets age-related skin damage repair. It exhibits chemotactic properties that promote dermal fibroblast migration, proliferation, and synthesis of macromolecules such as elastin and collagen, providing structural support to the skin





    Multi-Action Benefits

    Beyond elastin stimulation, Palmitoyl Hexapeptide-12 provides comprehensive skincare benefits:


    • Reduces appearance of fine lines and wrinkles by improving skin density and thickness
    • Enhances skin repair processes by accelerating cellular regeneration
    • Improves skin brightness and radiance by promoting healthier skin quality
    • Increases resistance to environmental damage by strengthening the skin's natural structure
    • Provides preventive anti-aging benefits when used regularly 




    Anti-Inflammatory Properties


    Research demonstrates that Palmitoyl Hexapeptide-12 can reduce interleukin-6 (IL-6) production in key skin cells, including keratin-forming cells and fibroblasts. Since IL-6 promotes inflammation and accelerates skin matrix degradation, this reduction helps slow down skin matrix breakdown, resulting in fewer wrinkles and improved skin tightness and elasticity 





    Enhanced Safety Profile

    Unlike some active ingredients, our Palmitoyl Hexapeptide-12 offers:

    • Non-irritating application through topical formulations
    • Excellent tolerance even for sensitive skin types
    • No recovery time or associated procedure risks
    • Suitable for long-term use without safety concerns 




    Formulation Versatility

    Our Palmitoyl Hexapeptide-12 is compatible with various formulation systems including:

    • Water-based serums and solutions
    • Oil-in-water and water-in-oil emulsions
    • Advanced delivery systems for enhanced penetration
    • Various cosmetic formulations including creams, lotions, and serums 




    Excellent Stability

    Rigorous stability testing confirms that our Palmitoyl Hexapeptide-12 maintains consistent purity and performance when stored under recommended conditions (2-8°C, protected from light) and formulated in appropriate systems 






    Applications & Formulation Guidance

    Our Palmitoyl Hexapeptide-12 is suitable for a wide range of skincare applications:


    Recommended Product Categories


    • Anti-aging creams and serums for face and neck
    • Wrinkle reduction treatments and night products
    • Eye contour treatments for crow's feet and expression lines
    • Preventive aging products for younger demographics
    • Neck and décolletage creams for comprehensive care
    • Targeted treatments for specific wrinkle areas 





    Formulation Recommendations


    Table: Formulation Guidelines for Different Applications


    Product Type

    Recommended Usage

    Key BenefitsFormulation Tips
    Face Serums5-10 ppmIntensive wrinkle reductionIncorporate in water phase; add at low temperature (<40°C)
    Moisturizers2-5 ppmDaily prevention, mild correctionAdd during cooling phase; ensure pH compatibility
    Eye Products4-8 ppmCrow's feet reduction, expression line softeningCombine with soothing agents; ensure gentle formulation
    Preventive Products2-5 ppmEarly aging prevention, muscle relaxationSuitable for lighter textures; target younger demographics
    Targeted Treatments7-10 ppmFocused wrinkle correctionHigher concentrations for specific area treatment



    Synergistic Combinations

    For enhanced benefits, combine Palmitoyl Hexapeptide-12 with:


    • Other peptides (Palmitoyl Tetrapeptide-7) for synergistic increase in collagen and hyaluronic acid content in the skin 
    • Hyaluronic acid for hydration and plumping effects
    • Antioxidants (Vitamin C, E) for comprehensive protection
    • Niacinamide for barrier improvement and brightness
    • Growth factors for enhanced skin rejuvenation




    Stability Considerations


    To maximize stability and performance in formulations:


    • Maintain pH between 5.0-7.0 for optimal stability
    • Avoid prolonged heating above 40°C during manufacturing
    • Use appropriate preservatives in aqueous systems
    • Consider encapsulation for enhanced stability in challenging systems
    • Package in airless containers with UV protection to preserve efficacy






    Ordering Information & Customer Support

    We offer flexible ordering options to meet diverse customer needs:


    • Sample Availability: Available in 1g, 10g, and 100g sizes for formulation development


    • Minimum Order Quantity (MOQ): 1g for standard material


    • Standard Packaging: 1g glass vials with rubber stoppers for optimal preservation


    • Customization Options:
    1. Different purity grades  (95%, 98%, 99%)
    2. Customized documentation packages
    3. Exclusive rights for large volume orders
    4. Private labeling and OEM services


    • Lead Times: Samples within 3-5 business days, production quantities in 2-3 weeks


    Our technical support team provides comprehensive assistance including:


    • Formulation guidance and compatibility testing
    • Regulatory support for different markets (EU, USA, ASEAN, etc.)
    • Stability testing protocols and assistance
    • Claims support with clinical data references
    • Custom development for specific application needs







    Contact Us for Samples & Technical Information

    Ready to enhance your formulations with premium Palmitoyl Hexapeptide-12?

    Contact our technical specialists today to discuss your specific requirements, request samples, or obtain detailed technical documentation.



    Please include in your inquiry:

    • Your company information and intended applications
    • Required quantity and specifications
    • Any specific customization needs
    • Target markets and regulatory requirements



    We respond to all inquiries within 24 business hours and are committed to building long-term partnerships through superior products and technical support.


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