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NIKOO Chemical - Skincare Raw Material Supply and Custom Solution Specialist for 15 years. 

Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 1
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 2
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 3
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 4
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 5
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 6
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 7
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 1
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 2
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 3
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 4
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 5
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 6
Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active 7

Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active

Brand Name:  NIKOOCHEM

Place of Origin:  Guangdong, China

Product Names:  Palmitoyl Tripeptide-1

Chemical Name: Palmitoyl Tripeptide-1

INCI: Palmitoyl Tripeptide-1

CAS: 147732-56-7

Molecular formula: C₃₀H₅₄N₆O₅
Molecular weight: 578.80 g/mol

Appearance:White to off-white powder or transparent liquid 

Purity: ≥98 %(HPLC)

Sequence:Palmitoyl-Gly-His-Lys

Solubility: Water-soluble (up to 30 mg/ml in DMF)

Storage:2-8°C, protected from light, desiccated

Shelf Life:24 months in original packaging

Recommended Usage: 2-10% in leave-on products

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    Palmitoyl Tripeptide-1 (Matrixyl 3000) - Premium Anti-Aging Peptide Active

    Next-Generation Collagen-Stimulating Peptide for Advanced Skincare Formulations


    Product Overview

    Our Palmitoyl Tripeptide-1 (INCI: Palmitoyl Tripeptide-1, CAS: 147732-56-7), also known as Pal-GHK or Matrixyl 3000, is a high-purity, bioactive peptide that represents cutting-edge innovation in non-invasive anti-aging skincare technology. As a leading Chinese manufacturer, we have developed a proprietary synthesis process that delivers Palmitoyl Tripeptide-1 with exceptional purity (≥98%) and unmatched bioactivity compared to traditional anti-aging ingredients .


    This revolutionary peptide ingredient offers targeted biological activity by stimulating collagen synthesis and extracellular matrix components without requiring injections. This makes it significantly more effective and less irritating than conventional approaches . Our Palmitoyl Tripeptide-1 is specially engineered for formulators seeking to create high-performance skincare products that deliver visible wrinkle reduction results within 30 days without causing sensitivity or irritation, even for consumers with sensitive skin .


    With its unique molecular structure that features a palmitic acid chain attached to a tripeptide sequence (Gly-His-Lys), our Palmitoyl Tripeptide-1 provides superior efficacy, enhanced skin compatibility, and prolonged activity in cosmetic formulations, making it the ideal choice for brands targeting consumers who seek clinical-grade results without invasive procedures 




    Advanced Production Process

    Our Palmitoyl Tripeptide-1 is manufactured through a proprietary liquid-phase synthesis technology that combines traditional peptide chemistry with advanced purification techniques:



    • Segmented Synthesis Approach: We utilize a patented liquid-phase method that involves synthesizing two key fragments separately: the dipeptide fragment H-His-Lys(Z)-OBzl and the palmitoyl-glycine fragment Pal-Gly-OH. These fragments are then combined using an activated ester method .
    • Fragment Preparation: The Pal-Gly-OH fragment is synthesized by reacting glycine with tertiary butanol followed by careful addition of palmitoyl chloride under controlled pH conditions (7.5-9.5) and temperature (below 5°C). The resulting compound is purified through recrystallization .
    • Peptide Coupling: The dipeptide fragment H-His-Lys(Z)-OBzl is prepared using Boc-protected chemistry, then coupled with the activated ester of Pal-Gly-OH (Pal-Gly-ONb or Pal-Gly-OSU) to form the protected peptide chain .
    • Deprotection and Purification: The fully protected peptide undergoes hydrogenation using Pd/C catalyst under controlled conditions to remove protecting groups, followed by purification through specialized solvent systems to achieve the final product 
    • Liquid Carrier-Assisted Synthesis (Alternative Method): We also employ an advanced liquid carrier-assisted technology that uses hydrophobic tags (Tag-A, Tag-B, Tag-C, or Tag-D) to facilitate reactions in halogenated solvents. This method allows for intermediate purification through precipitation in polar organic solvents, eliminating the need for hazardous hydrogenation steps .
    • Comprehensive Quality Control: Each batch undergoes rigorous analytical testing including HPLC for purity assessment, mass spectrometry for identity confirmation, amino acid analysis for composition verification, and stability testing under various conditions to ensure compliance with stringent quality standards 





    Factory Advantages & Manufacturing Capabilities

    As a leading manufacturer of advanced skincare active ingredients, we offer distinct advantages that make us the preferred partner for skincare brands worldwide:


    • Proprietary Synthesis Technology: Our advanced liquid-phase synthesis platform enables production of Palmitoyl Tripeptide-1 with exceptional purity (≥98%) and batch-to-batch consistency, overcoming traditional peptide synthesis challenges .
    • Significant Production Capacity: With large-scale production facilities and fully automated synthesis systems, we can reliably supply both small development quantities (from 1g) and large commercial volumes (kg scale) with consistent quality .
    • Customization Flexibility:We offer Palmitoyl Tripeptide-1 in various formulations including powder form (≥98% purity) and oil-soluble versions (100ppm concentration) for different application needs 




    Product Characteristics & Performance Benefits

    Our Palmitoyl Tripeptide-1 offers exceptional performance characteristics that make it ideal for advanced skincare formulations:



    Superior Collagen Stimulation

    Palmitoyl Tripeptide-1 demonstrates significant collagen production capabilities by promoting the synthesis of collagen types I and III in the dermal layer. Clinical studies show visible improvement in skin elasticity and firmness with regular use


    Mechanism of Action

    The peptide works as a matrikine signal peptide that interacts with skin cells to stimulate extracellular matrix components including collagen and glycosaminoglycans. This strengthens the dermal structure, resulting in thicker, firmer skin with reduced wrinkles 



    Multi-Action Benefits

    Beyond collagen stimulation, Palmitoyl Tripeptide-1 provides comprehensive skincare benefits:

    • Reduces appearance of fine lines and wrinkles by improving skin density and thickness
    • Enhances skin repair processes by accelerating cellular regeneration
    • Improves skin brightness and radiance by promoting healthier skin quality
    • Increases resistance to UV damage by strengthening the skin's natural structure
    • Provides preventive anti-aging benefits when used regularly 





    Enhanced Safety Profile

    Unlike some active ingredients, our Palmitoyl Tripeptide-1 offers:

    • Non-irritating application through topical formulations
    • Excellent tolerance even for sensitive skin types
    • No recovery time or associated procedure risks
    • Suitable for long-term use without safety concerns 




    Formulation Versatility

    Our Palmitoyl Tripeptide-1 is compatible with various formulation systems including:

    • Water-based serums and solutions
    • Oil-in-water and water-in-oil emulsions
    • Advanced delivery systems for enhanced penetration
    • Copper-complexed formulations for enhanced activity 




    Excellent Stability

    Rigorous stability testing confirms that our Tripeptide-1 maintains consistent purity and performance when stored under recommended conditions (2-8°C, protected from light) and formulated in appropriate systems. Advanced stabilization technologies allow our peptide to maintain stability even at 45°C for up to 3 months 






    Applications & Formulation Guidance

    Our Palmitoyl Tripeptide-1 is suitable for a wide range of skincare applications:


    Recommended Product Categories


    • Anti-aging creams and serums for face and neck
    • Wrinkle reduction treatments and night products
    • Eye contour treatments for crow's feet and expression lines
    • Preventive aging products for younger demographics
    • Neck and décolletage creams for comprehensive care
    • Targeted treatments for specific wrinkle areas





    Formulation Recommendations


    Table: Formulation Guidelines for Different Applications


    Product Type

    Recommended Usage

    Key BenefitsFormulation Tips
    Face Serums5-10 %Intensive wrinkle reductionIncorporate in water phase; add at low temperature (<40°C)
    Moisturizers3-7 %Daily prevention, mild correctionAdd during cooling phase; ensure pH compatibility
    Eye Products4-8 %Crow's feet reduction, expression line softeningCombine with soothing agents; ensure gentle formulation
    Preventive Products2-5 %Early aging prevention, muscle relaxationSuitable for lighter textures; target younger demographics
    Oil-Based Formulas1-4 % (oil-soluble version)Compatibility with anhydrous systemsUse specialized oil-soluble version for full oil formulas 



    Synergistic Combinations

    For enhanced benefits, combine Palmitoyl Tripeptide-1 with:


    • Hyaluronic acid for hydration and plumping effects
    • Antioxidants (Vitamin C, E) for comprehensive protection
    • Other peptides (Matrixyl, Argireline) for multi-mechanism action
    • Niacinamide for barrier improvement and brightness
    • Growth factors for enhanced skin rejuvenation




    Stability Considerations


    To maximize stability and performance in formulations:


    • Maintain pH between 5.0-7.0 for optimal stability
    • Avoid prolonged heating above 40°C during manufacturing
    • Use appropriate preservatives in aqueous systems
    • Consider encapsulation for enhanced stability in challenging systems
    • Package in airless containers with UV protection to preserve efficacy






    Ordering Information & Customer Support

    We offer flexible ordering options to meet diverse customer needs:


    • Sample Availability: Available in 1g, 10g, and 100g sizes for formulation development


    • Minimum Order Quantity (MOQ): 1g for standard material


    • Standard Packaging: 1g glass vials with rubber stoppers for optimal preservation


    • Customization Options:
    1. Different purity grades  (95%, 98%, 99%)
    2. Special oil-soluble versions (100ppm concentration) 
    3. Customized documentation packages
    4. Exclusive rights for large volume orders
    5. Private labeling and OEM services


    • Lead Times: Samples within 3-5 business days, production quantities in 2-3 weeks


    Our technical support team provides comprehensive assistance including:


    • Formulation guidance and compatibility testing
    • Regulatory support for different markets (EU, USA, ASEAN, etc.)
    • Stability testing protocols and assistance
    • Claims support with clinical data references
    • Custom development for specific application needs







    Contact Us for Samples & Technical Information

    Ready to enhance your formulations with premium Palmitoyl Tripeptide-1?

    Contact our technical specialists today to discuss your specific requirements, request samples, or obtain detailed technical documentation.



    Please include in your inquiry:

    • Your company information and intended applications
    • Required quantity and specifications
    • Any specific customization needs
    • Target markets and regulatory requirements



    We respond to all inquiries within 24 business hours and are committed to building long-term partnerships through superior products and technical support.


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