Palmitoyl Tripeptide-5 (Syn-Coll) - Premium Anti-Aging Peptide Active

Next-Generation Collagen-Stimulating Peptide for Advanced Skincare Formulations

Our Palmitoyl Tripeptide-5 (INCI: Palmitoyl Tripeptide-5, CAS: 623172-56-5), also known as Syn-Coll or Pal-Lys-Val-Lys, is a high-purity, bioactive signal peptide that represents cutting-edge innovation in non-invasive anti-aging skincare technology. As a leading Chinese manufacturer, we have developed a proprietary synthesis process that delivers Palmitoyl Tripeptide-5 with exceptional purity (≥98%) and unmatched bioactivity compared to traditional anti-aging ingredients .

This revolutionary peptide ingredient offers targeted biological activity by mimicking the natural extracellular matrix protein thrombospondin-1 (TSP-1), activating the TGF-β pathway to stimulate collagen production without requiring injections. This makes it significantly more effective and less irritating than conventional approaches . Our Palmitoyl Tripeptide-5 is specially engineered for formulators seeking to create high-performance skincare products that deliver visible wrinkle reduction results within 28 days without causing sensitivity or irritation, even for consumers with sensitive skin .

With its unique molecular structure that features a palmitic acid chain attached to the Lys-Val-Lys tripeptide sequence, our Palmitoyl Tripeptide-5 provides superior efficacy, enhanced skin penetration, and prolonged activity in cosmetic formulations, making it the ideal choice for brands targeting consumers who seek clinical-grade results without invasive procedures 

Our Palmitoyl Tripeptide-5 is manufactured through a proprietary liquid-phase synthesis technology that combines traditional peptide chemistry with advanced purification techniques:

• Activated Ester Method: We utilize a patented synthesis approach that involves preparing palmitic acid chloride and coupling it with the tripeptide sequence using activated ester chemistry. This method avoids repeated protection and deprotection steps, reducing costs and improving efficiency .
• Fragment Coupling: The process involves synthesizing two key fragments separately: the dipeptide fragment H-Val-Lys(Boc)-OH and the palmitoyl-lysine fragment Pal-Lys(Boc)-OSu. These fragments are then coupled using specialized coupling reagents under controlled conditions .
• Hydrogenation Deprotection: The fully protected peptide undergoes hydrogenation using Pd/C catalyst under controlled conditions to remove protecting groups (Boc groups), followed by purification through specialized solvent systems .
• Crystallization Purification: Unlike traditional methods requiring HPLC purification, our innovative process allows final product purification through crystallization, significantly reducing production costs while maintaining high purity .
• Green Chemistry Principles: We employ mechanochemical synthesis methods using twin-screw extrusion (TSE) technology, which represents a green, scalable, and continuous process. This approach significantly reduces the need for potentially harmful solvents and reagents, minimizing environmental impact 
• Comprehensive Quality Control: Each batch undergoes rigorous analytical testing including HPLC for purity assessment, mass spectrometry for identity confirmation, amino acid analysis for composition verification, and stability testing under various conditions to ensure compliance with stringent quality standards

As a leading manufacturer of advanced skincare active ingredients, we offer distinct advantages that make us the preferred partner for skincare brands worldwide:

• Proprietary Synthesis Technology: Our advanced liquid-phase synthesis platform enables production of Palmitoyl Tripeptide-1 with exceptional purity (≥98%) and batch-to-batch consistency, overcoming traditional peptide synthesis challenges .
  
• Significant Production Capacity: With large-scale production facilities and fully automated synthesis systems, we can reliably supply both small development quantities (from 1g) and large commercial volumes (kg scale) with consistent quality .
  
• Customization Flexibility: We offer Palmitoyl Tripeptide-5 in various purity grades (95%, 98%, 99%) and can provide custom formulations tailored to specific application needs .
  

Our Palmitoyl Tripeptide-5 offers exceptional performance characteristics that make it ideal for advanced skincare formulations:

Superior Collagen Stimulation

Palmitoyl Tripeptide-5 demonstrates significant collagen production capabilities by activating the TGF-β pathway, promoting the synthesis of collagen types I, III, and IV in the dermal layer. Clinical studies show visible improvement in skin elasticity and firmness with regular use

Dual Mechanism of Action

The peptide works through a sophisticated dual mechanism:

• Activates TGF-β pathway: Mimics thrombospondin-1 (TSP-1) to activate transforming growth factor beta (TGF-β), initiating the body's natural collagen production mechanism 
• Inhibits collagen degradation: Reduces matrix metalloproteinases (MMPs) activity by inhibiting inflammatory cytokines, preventing collagen breakdown

Multi-Action Benefits

Beyond collagen stimulation, Palmitoyl Tripeptide-5 provides comprehensive skincare benefits:

• Reduces appearance of fine lines and wrinkles by improving skin density and thickness
• Enhances skin repair processes by accelerating cellular regeneration
• Improves skin brightness and radiance by promoting healthier skin quality
• Increases resistance to UV damage by strengthening the skin's natural structure
• Provides preventive anti-aging benefits when used regularly 

Enhanced Safety Profile

Unlike some active ingredients, our Palmitoyl Tripeptide-5 offers:

• Non-irritating application through topical formulations
• Excellent tolerance even for sensitive skin types
• No recovery time or associated procedure risks
• Suitable for long-term use without safety concerns 

Formulation Versatility

Our Palmitoyl Tripeptide-5 is compatible with various formulation systems including:

• Water-based serums and solutions
• Oil-in-water and water-in-oil emulsions
• Advanced delivery systems for enhanced penetration
• Various cosmetic formulations including creams, lotions, and serums 

Excellent Stability

Rigorous stability testing confirms that our Palmitoyl Tripeptide-5 maintains consistent purity and performance when stored under recommended conditions (-20°C, protected from light) and formulated in appropriate systems

Our Palmitoyl Tripeptide-5 is suitable for a wide range of skincare applications:

Recommended Product Categories

• Anti-aging creams and serums for face and neck
• Wrinkle reduction treatments and night products
• Eye contour treatments for crow's feet and expression lines
• Preventive aging products for younger demographics
• Neck and décolletage creams for comprehensive care
• Targeted treatments for specific wrinkle areas

Formulation Recommendations

Table: Formulation Guidelines for Different Applications

Synergistic Combinations

For enhanced benefits, combine Palmitoyl Tripeptide-5 with:

• Growth factors for enhanced skin rejuvenation
• Hyaluronic acid for hydration and plumping effects
• Antioxidants (Vitamin C, E) for comprehensive protection
• Other peptides for multi-mechanism action
• Niacinamide for barrier improvement and brightness 

Stability Considerations

To maximize stability and performance in formulations:

• Maintain pH between 5.0-7.0 for optimal stability
• Avoid prolonged heating above 40°C during manufacturing
• Use appropriate preservatives in aqueous systems
• Consider encapsulation for enhanced stability in challenging systems
• Package in airless containers with UV protection to preserve efficacy

We offer flexible ordering options to meet diverse customer needs:

• Sample Availability: Available in 1g, 10g, and 100g sizes for formulation development

• Minimum Order Quantity (MOQ): 1g for standard material

• Standard Packaging: 1g glass vials with rubber stoppers for optimal preservation

• Customization Options:

1. Different purity grades  (95%, 98%, 99%)
   
2. Customized documentation packages
3. Exclusive rights for large volume orders
4. Private labeling and OEM services

• Lead Times: Samples within 3-5 business days, production quantities in 2-3 weeks

Our technical support team provides comprehensive assistance including:

• Formulation guidance and compatibility testing
• Regulatory support for different markets (EU, USA, ASEAN, etc.)
• Stability testing protocols and assistance
• Claims support with clinical data references
• Custom development for specific application needs

Ready to enhance your formulations with premium Palmitoyl Tripeptide-5?

Contact our technical specialists today to discuss your specific requirements, request samples, or obtain detailed technical documentation.

Please include in your inquiry:

• Your company information and intended applications
• Required quantity and specifications
• Any specific customization needs
• Target markets and regulatory requirements

We respond to all inquiries within 24 business hours and are committed to building long-term partnerships through superior products and technical support.