Skin "Screws" Collagen | Recombinant Humanized Type XVII Collagen

What is Type XVII Collagen?

Type XVII collagen is a signaling protein with a key-like structure. It achieves "cellular self-cleaning" (automatic removal of aging cells from the epidermis) by repairing the basement membrane through unique signal regulation, thereby improving skin texture.

Why Supplement with Type XVII Collagen?

1. Improves Skin Firmness: Strengthens skin structure and improves skin laxity.

2. Reduces Wrinkles: Supplements collagen and repairs broken collagen fibers.

3. Improves Skin Tone: Promotes skin health, reduces pigmentation, and brightens skin tone.

4. Strengthens the Skin Barrier: Enhances the skin's self-protective ability and defends against environmental damage.

Recent authoritative academic research indicates that Type XVII collagen is a key factor in cell regeneration and repair, playing an important role in resisting skin aging, controlling hair loss and graying, and promoting wound healing.

Recombinant Humanized Type XVII Collagen

Powerful Anti-Wrinkle, Firming Type XVII Active Collagen

Anti-wrinkle and Firming / Base Repair / Improved Sensitivity

Mechanism of Action of Type XVII Collagen

Adult stem cells (ASCs) are crucial for cell replacement in tissues. Their main function is to replace cells that may die due to disease or injury and maintain intracellular homeostasis, but their ability declines with age.

Human skin contains various types of stem cells, including epidermal stem cells, hair follicle stem cells, and melanocyte stem cells. These stem cells are key to regulating the skin aging process and are known as the "source of youth" for the skin.

Research shows that Type XVII collagen helps maintain the niche and function of stem cells by mediating interactions between stem cells and surrounding cells and the matrix, thereby coordinating skin homeostasis, promoting epidermal regeneration, and activating hair growth.

A 2019 study published in *Nature* revealed that type XVII collagen drives cellular competition, allowing higher-quality stem cells to prevail and eliminating damaged or unhealthy cells, thus combating skin aging.

The article points out that type XVII collagen decreases over time, a significant factor in skin aging, and maintaining its levels can reverse the aging process.

Another paper published in *Science* shows that hair follicle stem cells play a crucial role in hair regeneration, and the hydrolytic loss of type XVII collagen is one of the causes of their aging. Maintaining type XVII collagen levels can combat this aging process, thus alleviating hair loss symptoms.

Regarding wound repair, type XVII collagen accelerates wound healing by influencing stem cell population dynamics and regulating stem cell migration and proliferation.

Wide Range of Applications and Rapid Market Growth

Due to its effects in combating skin aging, maintaining skin structure and elasticity, promoting wound healing, and participating in hair follicle growth, type XVII collagen is increasingly being used in personal care, medical aesthetics, biomaterials, and hair regeneration.

Skincare Products: Type XVII collagen is expected to further enhance the anti-aging and moisturizing effects of cosmetics. By reducing the molecular weight of collagen, it can better penetrate the skin, achieving goals such as maintaining tissue homeostasis and resisting the aging process.

The market size of functional skincare products based on recombinant collagen was RMB 4.6 billion in 2021 and is projected to reach RMB 64.5 billion by 2027, with a compound annual growth rate of 52%.

Medical Aesthetics: Unlike type I and type III collagen, which act on the dermis, type XVII collagen acts on the basal layer of the epidermis, protecting and repairing the basement membrane. It can also promote the secretion of type I and type III collagen, so it is often used in combination to amplify its advantages.

For example, the "3+17 combined treatment" of type III and type XVII collagen is quite popular, with consumers applying type XVII collagen after type III collagen injections.

Medical Dressings: As a natural biomedical material, type XVII collagen plays a crucial role in skin wound repair through proliferation and healing, including promoting wound re-epithelialization, angiogenesis, and granulation tissue formation.

Data shows that the market size of medical dressings based on recombinant collagen was RMB 4.8 billion in 2021 and is projected to grow to RMB 25.5 billion by 2027, representing a CAGR of 31%.

Hair Care Products: In addition to basic moisturizing and scalp nourishment, type XVII collagen also possesses anti-gray hair and anti-hair loss effects, and is expected to shine in the hair care industry.

In the future, we will continue to launch more cutting-edge biotechnology raw materials and solutions, contributing more wisdom and strength to the development of the cosmetics industry.

If you are interested in the above raw materials/formulas or have other sample requests, please feel free to contact us.