Pentapeptide-18 (Leuphasyl) - Premium Anti-Aging Peptide Active

Next-Generation Neuropeptide for Advanced Skincare Formulations

Our Pentapeptide-18 (INCI: Pentapeptide-18, CAS: 64963-01-5), also known as Leuphasyl, is a high-purity, bioactive neuropeptide that represents cutting-edge innovation in non-invasive anti-aging skincare technology. As a leading Chinese manufacturer, we have developed a proprietary synthesis process that delivers Pentapeptide-18 with exceptional purity (≥98%) and unmatched bioactivity compared to traditional anti-aging ingredients .

This revolutionary peptide ingredient offers targeted biological activity by specifically mimicking the N-terminal end of SNAP-25 protein, competitively inhibiting neurotransmitter release without requiring injections. This makes it significantly more effective and less irritating than conventional approaches . Our Pentapeptide-18 is specially engineered for formulators seeking to create high-performance skincare products that deliver visible wrinkle reduction results within 30 days without causing sensitivity or irritation, even for consumers with sensitive skin .

With its unique molecular structure (Tyr-D-Ala-Gly-Phe-Leu) that features D-amino acids for enhanced stability, our Pentapeptide-18 provides superior efficacy, enhanced skin compatibility, and prolonged activity in cosmetic formulations, making it the ideal choice for brands targeting consumers who seek clinical-grade results without invasive procedures

Our Pentapeptide-18 is manufactured through a proprietary solid-phase peptide synthesis (SPPS) technology that combines Fmoc chemistry with advanced purification techniques:

• Resin Selection & Preparation: We utilize high-quality 2-chlorotrityl chloride resin or Rink Amide resin as the solid support, carefully prepared and activated to ensure optimal peptide chain assembly .
  
• Stepwise Peptide Assembly: Through automated peptide synthesizers, we add Fmoc-protected amino acids in sequential order using precise temperature-controlled reactions. Each amino acid addition follows a cycle of deprotection (using piperidine/DMF), coupling (with HBTU/HOBt activation), and washing steps to ensure complete reaction .
  
• Cleavage & Side Chain Deprotection: After complete peptide sequence assembly, the peptide-resin is treated with a specialized cleavage cocktail (typically TFA/water/triisopropylsilane) to simultaneously cleave the peptide from the resin and remove side chain protecting groups .
  
• Advanced Purification: The crude peptide undergoes multi-stage purification using preparative reverse-phase HPLC with C18 columns. This process ensures the removal of impurities while maintaining the structural integrity of the peptide molecules 
  
• Lyophilization & Quality Enhancement: The purified peptide solution undergoes freeze-drying to obtain the final powder form. The lyophilization process is carefully controlled to maintain peptide stability and ensure consistent performance in final formulations .
  
• Comprehensive Quality Control: Each batch undergoes rigorous analytical testing including HPLC for purity assessment, MS for molecular weight confirmation, amino acid analysis for composition verification, and stability testing under various conditions to ensure compliance with stringent quality standards

As a leading manufacturer of advanced skincare active ingredients, we offer distinct advantages that make us the preferred partner for skincare brands worldwide:

• Extensive Research Capabilities: With dedicated R&D centers and experienced peptide chemists, we maintain continuous innovation and product improvement, holding multiple patents related to peptide synthesis and purification technologies .
  
• Significant Production Capacity: we can reliably supply both small development quantities and large commercial volumes with consistent quality .
  
• Recognized Quality Standards: Our manufacturing facilities adhere to ISO 9001, GMP standards,  meeting international regulatory requirements for cosmetic ingredients .
  
• Customization Flexibility: We offer Pentapeptide-18 in various purity grades (95%, 98%, 99%) and can provide custom formulations tailored to specific application needs 

Our Pentapeptide-18 offers exceptional performance characteristics that make it ideal for advanced skincare formulations:

Superior Wrinkle Reduction Efficacy

Pentapeptide-18 demonstrates significant wrinkle reduction capabilities by inhibiting the release of neurotransmitters that cause muscle contractions. Clinical studies show visible reduction in wrinkle depth and expression lines with regular use

Mechanism of Action

The peptide works by mimicking the N-terminal end of SNAP-25 protein, competing with it for position in the SNARE complex. This inhibits the formation of the complex necessary for neurotransmitter release, effectively reducing muscle contractions that lead to expression lines and wrinkles

Multi-Action Benefits

Beyond wrinkle reduction, Pentapeptide-18 provides comprehensive skincare benefits:

• Prevents formation of new wrinkles by reducing repetitive muscle contractions
• Softens existing expression lines around eyes, forehead, and mouth
• Improves skin smoothness and texture by relaxing facial muscles
• Enhances overall skin appearance without affecting natural expressions
• Provides preventive anti-aging benefits when used regularly

Formulation Versatility

Our Pentapeptide-18 is compatible with various formulation systems including:

• Water-based serums and solutions
• Oil-in-water and water-in-oil emulsions
• Gel-based formulations
• Advanced delivery systems for enhanced penetration

Enhanced Safety Profile

Unlike injectable neurotoxins, our Pentapeptide-18 offers:

• Non-invasive application through topical formulations
• No risk of muscle paralysis or frozen expressions
• Excellent tolerance even for sensitive skin types
• No recovery time or associated procedure risks
• Suitable for long-term use without safety concerns 

Excellent Stability

Rigorous stability testing confirms that our Pentapeptide-18 maintains consistent purity and performance when stored under recommended conditions (-20°C, protected from light, desiccated) and formulated in appropriate systems 

Our Pentapeptide-18 is suitable for a wide range of skincare applications:

Recommended Product Categories

• Anti-aging serums and concentrated treatments
• Wrinkle reduction creams and night products
• Eye contour treatments for crow's feet and expression lines
• Preventive aging products for younger demographics
• Neck and décolletage creams for comprehensive care
• Targeted spot treatments for specific expression lines

Formulation Recommendations

Table: Formulation Guidelines for Different Applications

Synergistic Combinations

For enhanced benefits, combine Pentapeptide-18 with:

• Hyaluronic acid for hydration and plumping effects
• Antioxidants (Vitamin C, E) for comprehensive protection
• Other peptides (Matrixyl, Argireline) for multi-mechanism action
• Niacinamide for barrier improvement and brightness
• Growth factors for enhanced skin rejuvenation

Stability Considerations

To maximize stability and performance in formulations:

• Maintain pH between 5.0-7.0 for optimal stability
• Avoid prolonged heating above 40°C during manufacturing
• Use appropriate preservatives in aqueous systems
• Consider encapsulation for enhanced stability in challenging systems
• Package in airless containers with UV protection to preserve efficacy

We offer flexible ordering options to meet diverse customer needs:

• Sample Availability: Available in 1g, 10g, and 100g sizes for formulation development

• Minimum Order Quantity (MOQ): 1g for standard material

• Standard Packaging: 1g glass vials with rubber stoppers for optimal preservation

• Customization Options:

1. Different purity grades  (95%, 98%, 99%)
2. Customized documentation packages
3. Exclusive rights for large volume orders
4. Private labeling and OEM services

• Lead Times: Samples within 3-5 business days, production quantities in 2-3 weeks

Our technical support team provides comprehensive assistance including:

• Formulation guidance and compatibility testing
• Regulatory support for different markets (EU, USA, ASEAN, etc.)
• Stability testing protocols and assistance
• Claims support with clinical data references
• Custom development for specific application needs

Ready to enhance your formulations with premium Pentapeptide-18?

Contact our technical specialists today to discuss your specific requirements, request samples, or obtain detailed technical documentation.

Please include in your inquiry:

• Your company information and intended applications
• Required quantity and specifications
• Any specific customization needs
• Target markets and regulatory requirements

We respond to all inquiries within 24 business hours and are committed to building long-term partnerships through superior products and technical support.